## Admission requirements

This course is mandatory for and restricted to students who do the Minor ‘Computational approach to Disease Signaling and Drug Targets’ (CADSDT; the entire Minor or only Part 1), the Minor ‘Modern Drug Discovery’ (MDD) and the Elective Module ‘DSDT’. The same admission criteria apply to this course as for the respective aforementioned programs.

## Description

Computational Thinking is an essential skill for the 21st-century. With data gathering and algorithm development by Big Tech in the news regularly, such thinking is not only useful to understand the mechanisms underlying specific observations, but it is also indispensable to develop and apply modern computational approaches to solve the many open problems in the area of (computational) drug research. An important part of computational thinking is the ability to write computer scripts that execute well-defined computational tasks.

In this course, we will explore examples of computational thinking in drug research. We will provide an introduction to programming in R. Moreover, we will discuss mathematical equations, limits, partial derivatives and graphs of functions, which will subsequently be applied in the mathematical modeling of biological networks. We will also build upon previous statistics courses and explore the use of linear models for statistical inference testing and how to apply this in R. A substantial part of the course will be hands-on-training in scripting your own computer programs in R, with applications in mathematical modeling and using data sets that are relevant in drug research. In addition, computational thinking is highlighted in the context of chemogenomics. For this we will discuss how machine learning is used in chemogenomics to discover new drugs, techniques from this field are introduced, and peer reviewed literature is studied. Finally, we will bring these concepts together in a case study, where we will use these techniques on biomedical datasets.

## Course Objectives

The student is able to:

Solve mathematical equations, calculate limits and derivatives and draw graphs of functions

Analyze one-dimensional (1D) differential equations by pen and paper and interpret output from such analysis

Program an R-script to analyze mathematical equations including 1D differential equations

Program an R-script to format and analyze a (drug related) dataset and visualize the data

Choose and perform statistical inference tests using linear models in R on data that often arises in drug research, and draw conclusions from these tests

Select and discuss the optimal approach from an array of computational methods, for a given chemogenomic use case

## Timetable

An overview of the timetable will be published on the Brightspace module ‘Opleiding BFW Bachelor’ in August; a detailed schedule will be published on the Brightspace module of the course at least 4 weeks before the start of the Course.

## Mode of instruction

Practical course, consisting of: lectures, demonstrations, computer exercises, literature research and a group assignment.

## Assessment method

Students will be assessed on the following modalities:

A scripting test (20%)

Group data-analysis assignment (20%)

Exam (60%)

Total grade = 100%

In the written exam, a total of 60 points can be obtained, and the grade for the exam is determined by dividing the total number of obtained points by 6. Presence and active participation for the hands-on work during the course will be monitored and leads to a maximum of 6 points out of the 60 possible points on the written exam.

## Reading list

Literature will be provided during the course.

## Registration

Registration for the lectures and exam via uSis is mandatory.

## Coordinator

Dhr. G. Burger, MSc