Description
The purpose of this line course is to introduce basic pharmacological concepts that will help you in determining individualised treatment plans. For this it is important to know what a drug does to a patient (pharmacodynamics) and what happens with a drug in the body of the patient (pharmacokinetics).
Pharmacodynamics describe binding of drugs (to receptors, enzymes, channels, etc.) in order to exert their effects, how these effects occurs, and how they can be regulated. The autonomic nervous system is used as an illustration for this concept, since many drugs affect this system.
The absorption, distribution, metabolism, clearance and excretion are the main concepts described quantitatively in pharmacokinetics. These processes are influenced by many factors like organ dysfunction and disease. In order to make these concepts intelligible and their practical application clear, calculations (e.g. adjusting doses, calculating infusion rates) will be practised.
Course objectives
1 The student understands how medicines are handled by the body (pharmacokinetics) and how they act biologically (pharmacodynamics).
2 The student can apply these principles in simple medical problems.
3 The student can make pharmacokinetic calculations regarding absorption, distribution, clearance, excretion, and drug dosing.
4 The student understands different adverse effects and are able to explain adverse effects based on enlarged pharmacological action.
5 The student knows how to find and to interpret scientific information on new drug mechanisms and summarize this information in a report.
6 The student can construct a therapeutic plan according to the 6STEP method for an individual patient with a simple medical problem in a clear, concise and organised manner.
Timetable
All course and group schedules are published on our LUMC scheduling website or on the LUMC scheduling app.
Mode of instruction
Various teaching methods will be used in this module: ordinary lectures, seminars, self-study assignments, E-learning (Teaching Resource Centre and Pscribe).
Course load
Total course load is the amount of EC’s multiplied with 28 hours.
Assessment method
You are expected to be able to receive a 100% score on the comprehensive final exam. In order to ensure success on the final, you are given multiple opportunities to practice throughout the pharmacology course. Students that perform well throughout the module and participate actively with the quizzes during the workgroups are likely to achieve this course. It is your own responsibility to monitor your progress during the pharmacology module. You are encouraged to seek advice and assistance from the module coordinator, module committee, or workgroup tutors as soon as you encounter any difficulties in the module.
The distribution of course points will be as follows:
Quizzes (average grade from 3 different quizzes) 25%
Final exam 75%
Total 100%
Additionally to the final exam you are required to turn in two assignments. A group assignment about a new drug mechanism, and an individual assignment in Pscribe writing a 6STEP therapeutic plan of a patient case in Theme 9. If you do not send in your group assignment or 6STEP before the deadline, you will not receive your final grade of this module. Instructions of these assignments are on Blackboard.
The exam dates can be found on the schedule website.
For debriefing date; see Blackboard.
Blackboard
Blackboard will be used during this course.
Reading list
Reading: To enhance understanding of in-class lectures and discussions, and to keep pace during the pharmacology module, you should read the assigned sections prior to each scheduled meeting period. These will include:
Module book (available via Blackboard)
Teaching Resource Centre (TRC) pharmacology database (TRC website or TRC App)
Alternate required readings (if used) will be posted on Blackboard
Alternate readings: some of you may wish to utilize the following resources to enhance your understanding of the material. These include:
Rang & Dale’s Pharmacology, 8th Edition 2015
Farmacologie, 5e druk, Sitsen et al.
Algemene Farmacologie, 2e druk, van Ree en Breimer
Registration
Students are required to register for exams through uSis. The registration for a working group is done by handing in your ‘studieplan’.
Contact
Dr. Jeroen van Smeden
jvsmeden@chdr.nl
Dr. M.H.M. Hessel
M.H.M.Hessel@lumc.nl