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Studiegids

nl en

Molecular Biology and Oncology

Vak
2021-2022

Admission requirements

Knowledge about basic principles in Molecular Biology, Cellular Communication and Immunology is required.

Description

Cancer will be discussed in all its aspects, from basic genetics to treatment options in the clinic. Therefore, this module deals with general molecular biology, DNA replication and repair, transcription regulation, protein synthesis, molecular biology of viruses, cell cycle regulation, apoptosis, alterations in cell behaviour including the metastatic properties, interaction of tumour cells and stroma, angiogenesis, epidemiology and pathology of cancer, the immunological response to tumours, diagnosis and treatment of cancer, and new therapies on basis of the insights in cancer development.

Course objectives

The student:

  • explains how changes in molecular processes in a cell result in transformation to cancer (cell cycle, apoptosis, oncogenes and suppressor genes) and how the tumour microenvironment impact cancer progression (heterogeneity, angiogenesis, metastasis and immunity)

  • classifies tumours on basis of morphology, nomenclature and biological behaviour

  • translates and extrapolates molecular knowledge of cancer to current and future anticancer therapies

  • designs, performs and interprets representative experiments frequently used in cancer research

  • shows skills to report results in oral and written presentations.

Timetable

All course and group schedules are published on our LUMC scheduling website or on the LUMC scheduling app.

Mode of instruction

The major part of the program consists of self-study assignments that are discussed in workgroups. Some of the assignments have to be performed with the computer and answers have to be send by email. There are practicums that have to be designed and performed. Reports should be presented to prove that the experiments are understood. The experiments include: microscopic pathology and oncogenic transformation of cells in culture. A number of insight seminars will be given. Those seminars will discuss research that requires the knowledge that has been studied in this module. The clinical aspects will be illustrated with patient demonstrations.

Assessment method

The exam consists of 36 open questions. It is an open book exam. All practicums and obligatory assignments have to be executed sufficiently. One practicum report will be judged with a mark that counts for CIS.

Reading list

  • R.A. Weinberg, The Biology of Cancer. In addition some other books required in previous courses (kernboeken) may be used, such as:

  • B. Alberts et al., Molecular Biology of the Cell.

Registration

To participate in workgroups and exams students must register with uSis.

Contact

Remarks