Admission requirements
At start of the course, students should have basic knowledge in Epidemiology and Statistics, among which basic summary statistics, hypothesis testing, confidence estimation and linear regression.
Students are advised to update their background knowledge in Epidemiology by studying the MOOC https://www.coursera.org/learn/population-health-study-design and for Statistics the MOOC: https://www.coursera.org/learn/responsible-data-analysis.
More information will be provided to participants via mail and via Brightspace.
Description
Period: 27 September 2021 - 22 October 2021
In previous courses on epidemiology, data management, statistical software or (bio)statistics, you may have studied these subjects more or less as – stand alone – disciplines.
In practice however, research is only possible through strong interdisciplinary collaboration. This means that researchers must be able to combine and exploit knowledge across disciplines when formulating research questions based on a clinical problem, discussing and evaluating appropriate study designs, proposing the data collection and storage procedures and discussing the epidemiological and statistical analysis procedures, as well as software implementation which are appropriate. For these reasons, we will discuss in this course the practical problem of scientific research design and methods. We will start the course with the discussion of a real-life example in clinical scientific research. From this discussion, we will evaluate through a joint discussion which problems may be encountered when carrying out research and what the appropriate options are for study design and analysis. The focus of the course is thus on the interdisciplinary aspects of applied research and how epidemiology, (bio)statistics, software implementation and data management work together to help us solve practical research questions
Course objectives
You are able to design a study based on a clinical scientific problem, and understand the connection between epidemiological methodology, database design and management and concepts of statistical data analysis of clinical research questions.
You are able to discuss and evaluate the concepts and methods based on specific and precisely defined questions in clinical scientific research.
You can apply Directed Acyclic Graphs in the critical appraisals of study designs and for the causal interpretation of research findings.
You recognize the limitations of using crude epidemiological concepts such as relative risk and odds ratio, and know how to adjust these using statistical methods such as logistic regression and survival analysis.
You are able to apply these concepts, and formulate the results as well as the assumptions upon which results and evaluations are based.
You are able to apply these principles to your own study protocol.
Timetable
All course and group schedules are published on our LUMC scheduling website or on the LUMC scheduling app.
Mode of instruction
Lectures, workgroups, (computer) practical sessions, self study exercises.
Assessment method
Summative assessment:
- Written test (open book) with open questions
The exam dates can be found on the schedule website.
Reading list
An up-to-date working version of tThe programme SPSS has to be acquired from Surfspot: https://www.surfspot.nl/software.html.
The following is a list of English text books which are suitable for study. The course book contains an extended list of Dutch course texts as well, which may be used by students instead of the texts below.
Epidemiology. An introduction. K.J. Rothman. 2002, New York, Oxford University Press, ISBN 0-19-513554-7 (Alternative English book)
Epidemiology, beyond the basics. M. Szklo, F.J. Nieto. 2004, Sudbury Massachusetts, Jones and Bartlett Publishers, ISBN 0-7637-4722-X (for optional further reading)
Medical Statistics at a Glance. Aviva Petrie and Caroline Sabin, Blackwell Science, 200
Registration
Registration for FOS courses, H2W, Scientific Conduct, Course on Lab Animal Sciences and CRiP takes place in lottery rounds in the beginning of July. After the lottery rounds: if you want to register for a course you are kindly asked to contact the student administration at masterbms-courses@lumc.nl.