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Admission requirements

This course is mandatory for and restricted to students who do the Minor ‘Computational approach to Disease Signaling and Drug Targets’ (CADSDT; the entire Minor or only Part 1) or the Elective Module DSDT. The same admission criteria apply to this course as for the respective afore mentioned programs.


This course will cover the field of biomarker discovery and the application of biomarkers in drug development and patient care to enable personalized medicine. We discuss the use of high-dimensional molecular profiling technologies such as metabolomics and proteomics in conjunction with computational and state-of-the-art statistical approaches to identify, characterize and interpret biomarkers. The use of these particular techniques and approaches can be considered as systems approaches as they aim to understand biological system-specific changes associated with disease and pharmacological drug action. Examples of applications of biomarkers for diagnostics, disease progression and drug treatment response are presented. At the end of this course the student will have developed a broad overview of different approaches and technologies to discover and apply biomarkers in drug development and patient care.

Course Objectives

  1. Understanding of the scientific concepts underlying the research field of biomarker research and their application in drug development and personalized medicine.
  2. Understanding of state-of-the-art biomarker discovery approaches and experimental approaches in the field of biomarker research.
  3. Understanding of key data analysis and modeling methods used in the field of biomarker research


You will find the timetables for all courses and degree programmes of Leiden University in the tool MyTimetable (login). Any teaching activities that you have successfully registered for in MyStudyMap will automatically be displayed in MyTimeTable. Any timetables that you add manually, will be saved and automatically displayed the next time you sign in.
MyTimetable allows you to integrate your timetable with your calendar apps such as Outlook, Google Calendar, Apple Calendar and other calendar apps on your smartphone. Any timetable changes will be automatically synced with your calendar. If you wish, you can also receive an email notification of the change. You can turn notifications on in ‘Settings’ (after login).
For more information on MyTimeTable, watch the video or go the the 'help-page' in MyTimetable.

Always check the detailed schedule on the Brightspace module of each Course 2-3 weeks before the start of the Course for group-specific meetings, (intermediate) deadlines, etc..

Mode of instruction

  • Lectures

  • Hands-on exercises

  • Case study

Assessment method

The final grade will be the based on the grade of the written exam (individual grade) and the oral presentation according to a 70/30 ratio. Students will pass the course if the grade for the written exam is ≥ 5.0 and their average grade is ≥ 6.

Reading list

Literature will be provided during the course.



Dhr. Dr. J.G.C. van Hasselt