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Synthetic Organic Chemistry


Admission requirements & Registration

This course is mandatory for students who do the Minor ‘Modern Drug Discovery’ (MDD) and these students will be given priority. Additional places may be available to students outside the minor under the condition that they meet the admission requirements. The same admission requirements apply to this course as for the entire Minor MDD. Application for students outside the Minor MDD occurs via the study advisers of Bio-Pharmaceutical Sciences, LST or MST. Registration for the lectures and exam via MyStudyMap is mandatory.

Students from the MSc Chemistry and MSc LST are not allowed to include both this course and the course Molecular Chemistry (4423MCHEM) in their programme.


Strategies for the synthesis of current and newly developed drugs are discussed, including the mechanisms of reactions, functional group transformations, the use of protective groups, control of regio-, chemo- and stereoselectivity.

Course Objectives

After the course students:

  • Will have knowledge of the relation of structure and reactivity of organic molecules;

  • Will have knowledge of the mechanisms of standard chemical reactions, with a focus on functional group conversions;

  • Will have knowledge of chemical concepts such as, acidity, basicity, delocalization, conjugation, aromaticity, stereochemistry, tautomerism, regio-, chemo- and stereoselectivity.

  • Will be able to apply the chemical concepts;

  • Will be able to predict the structures of products of standard reactions;

  • Will be able to predict the required reagents for standard reactions;

  • Will be able to describe the mechanism of reactions.


You will find the timetables for all courses and degree programmes of Leiden University in the tool MyTimetable (login). Any teaching activities that you have successfully registered for in MyStudyMap will automatically be displayed in MyTimeTable. Any timetables that you add manually, will be saved and automatically displayed the next time you sign in.
MyTimetable allows you to integrate your timetable with your calendar apps such as Outlook, Google Calendar, Apple Calendar and other calendar apps on your smartphone. Any timetable changes will be automatically synced with your calendar. If you wish, you can also receive an email notification of the change. You can turn notifications on in ‘Settings’ (after login).
For more information on MyTimeTable, watch the video or go the the 'help-page' in MyTimetable.

Always check the detailed schedule on the Brightspace module of each Course 2-3 weeks before the start of the Course for group-specific meetings, (intermediate) deadlines, etc..

Mode of instruction

Lectures with active participation of the student

Assessment method

Written exam

Reading list

  • Organic Chemistry, Clayden, Greeves and Warren; OUP Oxford, 2nd edition, ISBN 9780199270293 (mandatory)

  • Literature will be provided during the course.


Dhr. Dr. D.V. Filippov