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Bioanalytical Mass Spectrometry


Admission requirements

Students of Master Bio-Pharmaceutical Sciences. The course is also opened to students from other Master programs. Interested students should then contact the course coordinators to discuss the possibilities.


This course focuses on the techniques, the instrumentation and applications of Mass Spectrometry in bioanalysis. The lectures give all the basics to understand Mass Spectrometry, including principle, ion sources, mass analyzers, detectors, data handling and spectral interpretation. A special attention is also put on separation techniques used in combination with Mass Spectrometry, and how to hyphenate such techniques. Finally, external speakers from university, medical centers, and/or the (pharma) industry highlight how Mass Spectrometry can be used in today’s science, within different bioanalytical applications.

Course objectives

The main objectives of the course BMS is to provide the students with:

  • The basic working principle of mass spectrometry (MS), including background, mechanisms, ionization, instrumentation, spectral interpretation, as well as hyphenation to chromatographic and electrophoretic techniques.

  • The latest developments of MS technology and future trends in bioanalysis.

  • A deep insight of the current MS applications in bioanalysis, biomedical and/or biopharmaceutical research.


You will find the timetables for all courses and degree programmes of Leiden University in the tool MyTimetable (login). Any teaching activities that you have sucessfully registered for in MyStudyMap will automatically be displayed in MyTimeTable. Any timetables that you add manually, will be saved and automatically displayed the next time you sign in.

MyTimetable allows you to integrate your timetable with your calendar apps such as Outlook, Google Calendar, Apple Calendar and other calendar apps on your smartphone. Any timetable changes will be automatically synced with your calendar. If you wish, you can also receive an email notification of the change. You can turn notifications on in ‘Settings’ (after login).

For more information, watch the video or go the the 'help-page' in MyTimetable. Please note: Joint Degree students Leiden/Delft have to merge their two different timetables into one. This video explains how to do this.

Mode of instruction

Lectures, tutorials, self-study.

Assessment method

The assessment comprises a group assignment (presentation, 40% of the final grade) and a written exam (60% of the final grade).
Students need at least a 5.0 for the exam and at least a 5.0 for the assignment/presentation. Not more than one 5.0 is allowed in total. The final grade should be 6.0 to successfully complete this course.

The final grade is expressed using an integer between 1 and 10 and can be rounded off/up to a half integer, with the exception of the grade 5.5. Final grades between 5.50 and 5.99 will be rounded up to 6.0.

Reading list

Will be announced during the lectures.


From the academic year 2022-2023 on every student has to register for courses with the new enrollment tool MyStudyMap. There are two registration periods per year: registration for the fall semester opens in July and registration for the spring semester opens in December. Please see this page for more information.

Please note that it is compulsory to both preregister and confirm your participation for every exam and retake. Not being registered for a course means that you are not allowed to participate in the final exam of the course. Confirming your exam participation is possible until ten days before the exam.

Extensive FAQ's on MyStudymap can be found here.


Coordinators: Dr. Ahmed Ali and Ischa Bremer (


A minimum of 5 participants is required. The maximal amount of participants is 40.

This information is without prejudice. Alterations can be made for next year.