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Reactivity in Organic Chemistry (ROC)


Admission requirements

Core course in MSc Chemistry – Chemical Biology, elective course MSc Chemistry, MSc Life Science and Technology.
For students with a BSc in MST, LST or equivalent. Knowledge of organic chemistry at the level of OC-II (BSc in Chemistry, Molecular Science and Technology, Life Science and Technology or a related discipline) is required.


The course provides the theoretical background necessary for in-depth understanding of organic reaction mechanisms. The course will focus on the role of stereo-electronic factors and conformational effects on the reactivity of molecules, identifying relevant HOMO-LUMO interactions and the application of (simplified) thermodynamics and kinetics, transition state theory and equilibria to understand and predict product distribution in organic reactions.

Course objectives

After the course the student has shown

  • Comprehension/application of reaction mechanisms of the most common transformations in organic chemistry;

  • Comprehension/application of orbital interactions to predict and rationalize reactivity;

  • Comprehension/application of stereoelectronic effects to predict and rationalize reactivity;

  • Comprehension/application of conformational equilibrium and their influence on reactivity;

  • Understanding of pericyclic reactions;

  • Prediction of regio- and stereoselectivity of common organic reactions based on reactivty principles;


Schedule information can be found on the website of the programmes.

You will find the timetables for all courses and degree programmes of Leiden University in the tool MyTimetable (login). Any teaching activities that you have sucessfully registered for in MyStudyMap will automatically be displayed in MyTimeTable. Any timetables that you add manually, will be saved and automatically displayed the next time you sign in.

MyTimetable allows you to integrate your timetable with your calendar apps such as Outlook, Google Calendar, Apple Calendar and other calendar apps on your smartphone. Any timetable changes will be automatically synced with your calendar. If you wish, you can also receive an email notification of the change. You can turn notifications on in ‘Settings’ (after login).

For more information, watch the video or go the the 'help-page' in MyTimetable. Please note: Joint Degree students Leiden/Delft have to merge their two different timetables into one. This video explains how to do this.

Mode of instruction

The class will be given through online classes, online tutorials and on campus tutorials.

Assessment method

Written mid-term test (open book, max 1 bonus point)
Written exam (open book, 100% of total grade)

Reading list

Clayden, Greeves & Warren, Organic Chemistry, 2nd edition, 2012. ISBN: 978-0-19-927029-3


From the academic year 2022-2023 on every student has to register for courses with the new enrollment tool MyStudyMap. There are two registration periods per year: registration for the fall semester opens in July and registration for the spring semester opens in December. Please see this page for more information.

Please note that it is compulsory to both preregister and confirm your participation for every exam and retake. Not being registered for a course means that you are not allowed to participate in the final exam of the course. Confirming your exam participation is possible until ten days before the exam.

Extensive FAQ's on MyStudymap can be found here.


Dr. Jeroen Codee, Dr. Dima Filippov


According to OER article 4.8, students are entitled to view their marked examination for a period of 30 days following the publication of the results of a written examination. Students should contact the lecturer to make an appointment for such an inspection session.