Admission requirements
Elective course in MSc Life Science and Technology and MSc Chemistry
For students with a BSc in LST, MST, BFW, Biology or equivalent. Students must have followed the course Molecular Genetics I or a similar course dealing with basic aspects of replication, transcription and translation, DNA, RNA and protein structure.
Description
The course deals with the fundamental aspects of virus replication with emphasis on RNA viruses. Topics addressed include discovery and classification of viruses, virus structure, viral entry pathways, translation and replication strategies, encapsidation, egress and evolution. These topics are illustrated by examples of HIV, influenza virus, coronavirus, poliovirus, plant viruses and bacterial viruses. Anti-viral strategies and applications are also discussed. First part of the course deals with lectures on the important steps in the viral life cycle and is concluded by a written exam. The second part discusses several viruses in more detail including methods to study their replication and evolution, and ways to beat them. This part is concluded by a second written exam.
Course objectives
At the end of the course students
have knowledge of fundamental principles of virology
know the basis of virus classification and are able to sketch the important steps in the viral life cycle.
know the basic composition of virus particles.
understand the various tricks that viruses use to express their genes.
know how to study and manipulate RNA viruses.
know how to tackle and interfere with viral replication.
are able to predict the effect of certain mutations on the replication of a virus and how to test this prediction experimentally.
Timetable
Schedule information can be found on the website of the programmes.
You will find the timetables for all courses and degree programmes of Leiden University in the tool MyTimetable (login). Any teaching activities that you have sucessfully registered for in MyStudyMap will automatically be displayed in MyTimeTable. Any timetables that you add manually, will be saved and automatically displayed the next time you sign in.
MyTimetable allows you to integrate your timetable with your calendar apps such as Outlook, Google Calendar, Apple Calendar and other calendar apps on your smartphone. Any timetable changes will be automatically synced with your calendar. If you wish, you can also receive an email notification of the change. You can turn notifications on in ‘Settings’ (after login).
For more information, watch the video or go the the 'help-page' in MyTimetable.
Mode of instruction
Lectures
Assessment method
Two written exams, each counting for 50% of the final grade. The grade of each exam should be at least 5.5 to pass the course.
Reading list
Principles of Virology: Molecular Biology, Pathogenesis, and Control of Animal Viruses, 2nd Edition. S. J. Flint, L. W. Enquist, V. R. Racaniello, A. M. Skalka. (optional)
Powerpoint presentation is posted on Brightspace after each lecture.
Registration
Every student has to register for courses with the enrollment tool MyStudyMap. There are two registration periods per year: registration for the fall semester opens in July and registration for the spring semester opens in December. Please see this page for more information.
Please note that it is compulsory to register your participation for every exam and retake. Not being registered for a course means that you are not allowed to participate in the final exam of the course.
Extensive FAQ's on MyStudymap can be found here.
Contact
Remarks
According to OER article 4.8, students are entitled to view their marked examination for a period of 30 days following the publication of the results of a written examination. Students should contact the lecturer to make an appointment for such an inspection session.