In these lectures the BBB will be discussed in relation to drug transport to the brain, particularly with emphasis on the morphology, functionality and regulation of the BBB. Further, BBB functionality will be related to BBB permeability, drug transporters at the BBB and drug metabolism by the BBB. Special attention will be given to the influence of diseases at the BBB. Methods will be discussed to estimate in vitro and in vivo BBB functionality and permeability and a case study will be given to the students to be worked out during and discussed at the end of the course.
Coordinator
Dr. A.G. de Boer
Doelgroep
Students of Bio-Pharmaceutical Sciences and Biomedical Sciences
Toegangseisen
Theme drug effects (2)
Onderwijsvorm
lectures
Literatuur
a handout will be given at the beginning of the Caput Lecture Series
Toetsing
written exam
Doorgang
minimum of 5 students
Rooster
From 22 January to 5 March on Thursdays from 9.00 to 12.45 h. See the schedule of the lecture series in the master study guide 2008—2009.
For detailed information, see: Programme Caput Lectures Blood Brain Barrier (will be announced later).
Inschrijving
Via e-mail: B.Boer@LACDR.LeidenUniv.NL