Series of lectures and workshops will be given on understanding how global regulatory networks govern gene expression in bacteria, with comparison to (lower) eukaryotes. We will look at how environmental signals (e.g. nutrients, stress) are translated to switch sets of genes on and off, and how this affects metabolism, competence, development and antibiotic production. Focus is on E. coli, Bacillus and Streptomyces. This course includes workshops on use of the databases and regulon prediction programs.