Thorough basic knowledge of principles of neuroscience is essential; successful completion of the second year course “Introduction in the Neuroscience”, or a similar course is mandatory.
Bear, Connors and Paradiso; Neuroscience, Exploring the Brain.; 3rd Ed. 2006; Ch 2-7 and 9-14.
Successful completion of How to write a research proposal is strongly recommended.
Period: June 6 – June 24, 2011
The first week of the course will be dedicated to the introduction of in vitro and in vivo neuroimaging techniques of increasing complexity (Rx, EEG, evoked potentials, CT, PET, MRI, multiphoton microscopy, in vivo confocal microscopy, calcium imaging, SPECT, SQUID). Each technique will be presented in a practical context, i.e. in terms of what questions (research, clinical) can be answered with the technique in question. Students will then read selected papers, collate information gained in small groups and prepare a review presentation.
The second week will be an in depth case study of the imaging techniques applied in a disease model, in casu migraine. During this week workgroups will be supplied with research hypotheses and asked to formulate an imaging experiment to resolve the hypotheses. Ideally these experiments will be performed at the end of the week.
During the third week workgroups will be supplied with pre-existing neuroimaging data, and a matching hypotheses and be requested to analyse the data and to write a short paper based on the analysis.
This course will work on:
Creative thinking, rapid acquisition of new knowledge, information gathering
Formulating a relevant and feasible research strategy, data analysis, writing a paper
Collaboration with peers, commitment, motivation and drive, digesting other peoples opinion, peer review
Oral and written presentations; writing a paper
gains a thorough understanding of the various neuroimaging techniques used in fundamental research and in clinical practice;
is able to design an imaging experiment to resolve hypotheses related to cognition or pathology;
is able to interpret experimental data in one of the neuroimaging techniques and to write a short paper based on these data.
Mode of instruction
Lectures, group work, self study assignments, practical.
Oral presentation, research proposal/question, active participation, written report