- Successful completion of Clinical Research in Practice is strongly recommended.
- No special requirements in addition to indicated level, except that participants are expected to speak Dutch fluently. Because the course will be in Dutch.
Period: This course will nog be taught in 2011-2012, but in 2012-2012. The description below is indicative for the course contents but may be updated by May/June 2012.
Thrombosis is the major cause of death in western cultures. It may occur in arteries (myocardial infarction, stroke) and veins (deep-vein thrombosis, pulmonary embolism). Particularly in venous thrombosis abnormalities affecting blood coagulability play an important role. These may be genetic (e.g., factor V Leiden) or acquired (e.g., oral contraceptives). Recently, research has successfully focussed on identifying new genetic risk factors for thrombosis, and their interaction with acquired factors.
- students will perform a clinical scientific study, related to thrombosis, in which they will pass through all phases of a research project: posing a research question, finding a study design, setting up the study (questionnaire, lab, grant), data-cleaning, analysis and reporting.
- in this study students will work on actual data, that are part of an on-going study on venous thrombosis.
- students will work out four parallel subprojects on various risk factors (e.g., type of oral contraceptive, travel, exercise, obesity, factor V Leiden gene mutation, pregnancy/puerperium).
- site visits will be part of the course, in which students will interview people, for instance a patient with thrombosis, and professionals (physicians, biochemists, Ph.D. students, fieldworkers, technicians) who are involved in clinical care and studies such as these.
This course will particularly work on:
Choosing appropriate techniques, recording, organizing and analyzing data, relate experimental results to those of others
Collaborating with peers, commitment, motivation and drive, digesting of other people’s opinions, reflecting on personal actions.
To get a good understanding into:
- hands-on comprehensive experience in clinical research (translational research). During this course, clinical problems and biochemical possibilities are translated into a scientific study. The course also shows how this scientific study can be translated back to clinical practice.
- how to write a Research Letter or Short Report.
The students will be part of all phases of a study, and obtain understanding for what needs to be done to obtain a dataset, and how to get the best data, related to venous thrombosis.
Mode of instruction
Interactive lectures, practicals, work groups, patient demonstrations.
Writing of a research letter or short report; oral presentation of assignment; student behaviour (motivation, independency, oral reporting, participation in discussion).