The development of new drugs with an action on the central nervous system (CNS) is notoriously difficult. For a proper CNS effect, the drug should have the ability to cross the BBB, and then has to find its way to the relevant target site within the CNS. This course will address the role and function of the Blood-Brain Barrier (BBB) and brain tissue distribution in research concerning CNS drug development, CNS drug delivery and CNS diseases. It will provide profound insight in the complex function of the BBB with regard to transport kinetics in health and disease.
The series of lectures will include the following themes; 1) basic aspects of the BBB, 2) In vitro and in vivo methods for investigation of BBB transport and distribution within the brain, and 3) pharmaco-kinetics of CNS drug delivery.
Coordinator
Dr. E.C.M. de Lange
Students
Students of Bio-Pharmaceutical Sciences and Biomedical Sciences
Admittance demands
Theme drug effects (2)
Method of instruction
lectures
Required reading
a handout will be given at the beginning of the Lecture Series
Examination
written exam
minimal number of students
minimum of 8 students
Time table
Mondays:
June: 11, 18, 25
July: 2 and 9
Time: 10.00—12.00 h
Exam: Friday July 13, 9 AM, C1
Application
Via e-mail: l.lange@lacdr.leidenuniv.nl
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