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Physiology, Advanced Concepts

Vak 2013-2014

Admission requirements

The course Physiology, Advanced Concepts, is meant for the student who has already followed the course Physiology, Basic Concepts, or has a comparable level of knowledge on cardiovascular, respiratory and renal physiology.


Period: January 6 -17, 2014

This course concentrates on two organ systems, for which the following topics are taught:

1. Cardiovascular System

  • endothelial control of the circulation
  • endothelialization
  • angiogenesis

2. Integration of water, salt and electrolyte balance; Regulation of the effective circulating volume.

  • osmoregulation
  • volume regulation
  • acid-base regulation

Course objectives

After having followed this course, the student can describe and mechanistically explain how the circulation, endocrine system and kidneys contribute to an adequate perfusion of body tissues, to the regulation of the circulating blood volume, blood (and cellular) osmolarity and electrolyte homeostasis.

Mode of instruction

This course has no practicals or working groups, and has a different pace with in-depth lectures (about 15). For every 2 lectures an interactive tutorial with on-line voting is held.

Assessment method

Multiple choice exam.

Reading list

  • Boron WF & Boulpaep EL, 2009 (second edition): Medical physiology: a cellular and molecular approach
  • (on internet

Information for exchange students

This module is part of an English taught semester of the bachelor’s programme in Biomedical Sciences at Leiden University Medical Center. Combining biomedical modules with modules from other programmes in Leiden is difficult or impossible due to different scheduling schemes. Exchange students with sufficient relevant background knowledge in biology/biomedicine are therefore encouraged and advised to choose the entire module package indicated below. This semester starts in week 36 and finishes at the end of week 3 of the following calendar year.

  • Immunology (BW), 8 EC
  • Pathogen-Host Interactions part 2, 3 EC
  • Infection and Immunity in Practice, 3 EC
  • Physiology, Basic Concepts, 8 EC
  • Physiology, Advanced Concepts, 3 EC
  • Communication in Science for Exchange students, 1 EC