The module Mechanisms of Disease 1 elaborates on the first year modules of Medicine in which the normal anatomy, physiology and homeostasis were taught. Disease results from a disturbance in the structural integrity and/or normal function of (part of) the body and/or the response to this disturbance. The second year starts with the modules Mechanisms of Disease 1 and 2, focussing on the 7 different mechanisms of disease: growth disorders, metabolic and degenerative disorders, congenital abnormalities, hemodynamic disorders, acute and chronic inflammation, disordered immunity and cell/tissue injury and repair.
In module G2MD1 the focus is mainly on inflammation, cell/tissue injury and repair and disordered immunity.
Themes of G2MD1
I.Normal host response to pathological stimuli
I.A. Overview of the defense mechanisms
I.B.Pathology of injury and repair
II.Micro-organisms as cause of disease
III.A. Host-pathogen interactions
III.B. Clinical aspects of infectious diseases: clinical presentations and diagnostics
III.C. Clinical aspects of infectious diseases: therapy
IV. Prevention and control
IV.A. Epidemiology of infectious diseases
IV.B. Prevention and control of infectious diseases
V.A. Hyper-responsiveness of the immune system to non-self: allergy
V.B. Clinical aspects of allergy: clinical presentations and diagnostics
V.C. Clinical aspects of allergy: therapy
VI.A. Hyper-responsiveness of the immune system to self: auto-immunity
VI.B. Clinical aspects of auto-immunity: clinical presentations and diagnostics
VI.C. Clinical aspects of auto-immunity: therapy
VII. Transplantation-associated pathology
- normal host defense mechanisms and response to injury
- histology of inflammation and repair, consequences for tissue/organ function
- classification, structure and physiology of micro-organisms
- pathogenesis of diseases resulting from interaction between the immune system and pathological stimuli (micro-organisms, antigens)
- failing defense mechanisms or hyper-responsiveness of the immune system (type I-IV allergies and auto-immune diseases)
- immunological principles of transplantation, pathogenesis of clinical problems associated with transplantation
- principles underlying interpretation of diagnostic test results
- for selected infections and immune disorders: clinical presentations, pathogenesis, diagnostic and therapeutic options
- pharmacotherapy: mechanism of action of immunosuppressive, immune enhancing and antimicrobial drugs
- principles of prevention and control of infectious diseases
Mode of instruction
In each theme, lectures will provide an overview of the subjects. Self-study is an important teaching method in this module, based on the study books, e-learning lessons and self-study assignments. In 3 interactive seminars the students’ knowledge of a theme is actively trained. In 4 work groups the students will work together on specific assignments. Two microscopy practicals (bacteriological and parasitological diagnostics) provide a case- based practice of interpretation of microbiological microscopy.
40 Lectures, 3 seminars, 6 patient demonstrations, various e-learning modules (e.g. 3 diagnostics modules,TRC pharmacology database), 2 obligatory practicals, 4 work groups
- weekly formative tests (either in lecture hall, at home or during practical or work group)
- summative tests consist of 3 concise component exams in the course of the module (multiple choice, open questions) and 1 final ) and 1 final examination (extended matching, multiple choice and integrated puzzle) in week 6.
- P. Parham. The immune system, 3rd edition, 2009
- Robbins and Cotran Pathologic Basis of Disease, 8th edition, 2009.
- Ryan and Ray. Sherris Medical Microbiology. 5th edition, 2010
- Skolnic; Global Health 101, 2nd edition 2012 (ISBN-13: 9780763797515)
“Secretariat of the Department of Pathology”