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Global Regulatory Networks in Bacteria (GRNB)


Actual course information
Up to date schedule information

Core course in MSc Life Science and Technology, elective course MSc Chemistry


MSc students from Life Science and Technology

Contact information

Coordinator: prof. Dr. G.P. van Wezel


Series of lectures, selection of research papers on related topics and workshops will be given on understanding how global regulatory networks govern gene expression in bacteria, with comparison to (lower) eukaryotes. We will look at how environmental signals (e.g. nutrients, stress) are translated to switch sets of genes on and off, and how this affects metabolism, competence, development and antibiotic production. Furthermore protein secretion will be discussed. Focus is on E. coli, Bacillus, Streptomyces and fungi. This course includes workshops on use of the databases and regulon prediction programs and writing of a research proposal.

Learning goals

Course objectives: Provide an up-to-date overview of the latest results published on the topics discussed during the lectures. Students will learn to use this knowledge in answering typical research questions and to apply their knowhow in writing a concise research proposal.


From 10 February to 4 April 2014. The detailed timetable will be available on Blackboard.

Total number of contact hours

25 contact hours

Mode of instruction

Lectures and workshops

Assessment method

Written exam based on the lectures and a selection of review papers on topics discussed during the lectures. Students write a research proposal based on literature study and information obtained from research groups that participate in GRNB.


Blackboard will be used for communication.

Reading list



via Usis and enroll in Blackboard

Exchange and Study Abroad students, please see the Prospective students website for more information on how to apply.