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Signal Transduction and Hallmarks of Cancer (adapted from Molecular Mechanisms of Cell Death)

Vak 2015-2016

h3, Description and Course Objectives

Cancer is a complex disease in which mutations in the DNA cause aberrant cellular signaling that ultimately affects critical cell functions. Several hallmarks of cancer have been defined including cell autonomous aberrations affecting survival and proliferation as well as altered communication with the cancer microenvironment. These hallmarks allow tumors to develop, grow, metastasize, and evade therapies.

In this caput program, the different forms of signal transduction cascades mediating hallmarks of cancer are discussed. Lectures are combined with paper discussions to reach the following end goals of the course:

• Knowledge of the various hallmarks of cancer
• Knowledge of the signaling pathways in control of these hallmarks of cancer
• Understanding the complexity of the disease and how this complicates therapies but may also provide new avenues for therapy.

Coordinator

Dr. E. Danen

Toegangseisen

Basic knowledge of Cell Biology and Biochemistry.

Onderwijsvorm

Lectures

Literatuur

Albert et al, Molecular Biology of the Cell

Toetsing

Written Exam, active participation

Rooster

The course will be given on Wednesdays from February to March, details to be announced.

Inschrijving

Application via uSis.