The module Mechanisms of Disease 1 elaborates on the first year modules of Medicine in which the normal anatomy, physiology and homeostasis were taught. Disease results from a disturbance in the structural integrity and/or normal function of (part of) the body and/or the response to this disturbance. The second year starts with the modules Mechanisms of Disease 1 and 2, focussing on the 7 different mechanisms of disease: growth disorders, metabolic and degenerative disorders, congenital abnormalities, hemodynamic disorders, acute and chronic inflammation, disordered immunity and cell/tissue injury and repair.
In module G2MD1 the focus is mainly on inflammation, cell/tissue injury and repair and disordered immunity.
Themes of G2MD1
I.Normal host response to pathological stimuli.
I.A. Overview of the defense mechanisms
I.B.Pathology of injury and repair
II.Micro-organisms as cause of disease.
III.A. Host-pathogen interactions
III.B. Clinical aspects of infectious diseases: clinical presentations and diagnostics
III.C. Clinical aspects of infectious diseases: therapy
IV. Prevention and control
IV.A. Epidemiology of infectious diseases
IV.B. Prevention and control of infectious diseases
V. Allergy (hyper-responsiveness of the immune system to non-self)
V.A. Hyper-responsiveness of the immune system to non-self: allergy
V.B. Clinical aspects of allergy: clinical presentations and diagnostics
V.C. Clinical aspects of allergy: therapy
VI. Auto-immunity (hyper-responsiveness of the immune system to self)
VI.A. Hyper-responsiveness of the immune system to self: auto-immunity
VI.B. Clinical aspects of auto-immunity: clinical presentations and diagnostics
VI.C. Clinical aspects of auto-immunity: therapy
VII. Transplantation-associated pathology
normal host defense mechanisms and response to injury
histology of inflammation and repair, consequences for tissue/organ function
classification, structure and physiology of micro-organisms
pathogenesis of diseases resulting from interaction between the immune system and pathological stimuli (micro-organisms, antigens)
failing defense mechanisms or hyper-responsiveness of the immune system (type I-IV allergies and auto-immune diseases)
immunological principles of transplantation, pathogenesis of clinical problems associated with transplantation
principles underlying interpretation of diagnostic test results
for selected infections and immune disorders: clinical presentations, pathogenesis, diagnostic and therapeutic options
pharmacotherapy: mechanism of action of immunosuppressive, immune enhancing and antimicrobial drugs
principles of prevention and control of infectious diseases
Mode of instruction
In each theme, lectures will provide an overview of the subjects. Self-study is an important teaching method in this module, based on the study books, e-learning lessons and self-study assignments. In 3 interactive seminars the students’ knowledge of a theme is actively trained. In 4 work groups the students will work together on specific assignments. Two microscopy practicals (bacteriological and parasitological diagnostics) provide a case- based practice of interpretation of microbiological microscopy.
42 Lectures, 3 seminars, 6 patient demonstrations, various e-learning modules (e.g. 3 diagnostics modules, TRC pharmacology database), 2 obligatory practicals, 1 voluntary practical, 4 work groups
weekly formative tests (either in lecture hall, at home or during practical or work group)
summative tests consist of 1 component exam in week 4 of the module (multiple choice, open questions) and 1 final examination (extended matching, multiple choice and integrated puzzle) in week 6.
Immunology: The Immune System, 4th edition, Peter Parham, Garland Science 2014.
Infectious Diseases: Sherris Medical Microbiology, 6th edition. Ryan and Ray, McGraw Hill 2014.
Pathology: Kumar, Abbas and Fausto. Robbins and Cotran Pathologic Basis of Disease. Elsevier Saunders, 9th edition, 2013
Global health: Skolnik; Global Health 101, 2nd edition 2012
“Secretariat of the Department of Pathology”