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Systems Pharmacology



The aim of the research within the Systems Pharmacology cluster is to develop pharmacotherapy based on individual patient needs. We do this by combining advanced analytical tools from the Division of Analytical Biosciences and quantitative pharmacology concepts from the Division of Pharmacology. These core strengths meet in the field of Systems Pharmacology.
A wide range of experimental and computational methods are applied in our research, covering translational research from in vitro methods (e.g. organ-on-a-chip) and preclinical models (e.g. microdialysis) to humans, as well as direct patient-related research on clinical samples (e.g. metabolomics) or data (e.g. population modeling) obtained from collaborating hospitals. The research of the cluster Systems Pharmacology will be reflected in the minor Systems Pharmacology.

Course Objectives

#1 Obtaining an understanding of the main scientific concepts underlying the research field of Systems Pharmacology. #2 Obtaining an understanding of the relevance of Systems Pharmacology to develop a personalized medicine strategy.

Reading list

Literature will be provided during the course.


Dhr. Prof. Dr. M. Danhof and Mw. Dr. E. Krekels

Mode of instruction

There will be lectures on metabolomics and pharmacology and on different data analysis methods used in these fields. Students will get hands-on experience with some of these methodologies in hands-on sessions and they will work on a proposal for new research based on a case study.

Assessment method

The final grade will be the based on the grade of the written exam (individual grade) and of the oral presentation and written report of the case study (group grade), according to a 60/20/20 ratio. Students will pass the course if the grade for the written exam is ≥ 5.0 and their average grade is ≥ 5.5.

Admission requirements & Registration

This course is mandatory for students who do the Minor ‘Disease Signaling and Drug Targets’ (DSDT) and these students will be given priority. Ten additional places are available to students outside the minor under the condition that they meet the admission criteria. The same admission criteria apply to this course as for the entire Minor DSDT. Application for students outside the Minor DSDT occurs via the study advisers of Bio-Pharmaceutical Sciences only.