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Signal Transduction and Hallmarks of Cancer (adapted from Molecular Mechanisms of Cell Death)



Cancer is a complex disease in which mutations in the DNA cause aberrant cellular signaling that ultimately affects critical cell functions. Several hallmarks of cancer have been defined including cell autonomous aberrations affecting survival and proliferation as well as altered communication with the cancer microenvironment. These hallmarks allow tumors to develop, grow, metastasize, and evade therapies. In this caput program, the different forms of signal transduction cascades mediating hallmarks of cancer are discussed.


Dr. E. Danen

Admission requirements

Basic knowledge of Cell Biology and Biochemistry.

Mode of instruction

Lectures and paper discussions.

Reading list

Albert et al, Molecular Biology of the Cell; Hanahan D and Weinberg RA (2011) Hallmarks of Cancer: The Next Generation. Cell 144:646-674.

Course objectives

  • Knowledge of the various hallmarks of cancer

  • Knowledge of the signaling pathways in control of these hallmarks of cancer

  • Understanding the complexity of the disease and how this complicates therapies but may also provide new avenues for therapy.

Assessment method

Written Exam, active participation.


The course will be given on Wednesdays from February to March, details to be announced.


Application via uSis. Registration closes 1 month before the start of the course.