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Physiology, Advanced Concepts


Admission requirements

The course Physiology, Advanced Concepts, is meant for the student who has already followed the course Physiology, Basic Concepts, or has a comparable level of knowledge on cardiovascular, respiratory and renal physiology.


Period: March 6 – 24, 2017

This course focuses on impaired circulation as a result of inflammation, sepsis, endothelial dysfunction, thrombosis, atherosclerosis and vascular remodelling and its consequences for heart, lung and kidney physiology. Subtopics that will be discussed during the course are:

  • endothelial (dys)function

  • (ab)normal hemostasis

  • sepsis

  • vascular responses to Toll-like receptor activation

  • inflammatory & ischemic kidney disease

  • pulmonary arterial hypertension

  • atherosclerosis, coronary artery disease & myocardial infarction

  • heart failure: hemodynamic & electrophysiological effects

Course objectives

After having followed this course, students should have a clear understanding of the major pathophysiological processes involved in blood flow impairment and its consequences for heart, lung and kidney function.

Mode of instruction

This course consists of lectures, seminars, working groups and self-study assignments.

Assessment method

Multiple choice exam.

Exam dates

Exam: Friday March 24th 9.00-12.00h
Re-exam: Friday July 14th 13.00-16.00h

Reading list

  • Boron WF & Boulpaep EL. Medical physiology: a cellular and molecular approach. Second updated edition. 2012. Saunders Elsevier, Philadelpia, PA.

  • Levick JR. Introduction to cardiovascular physiology. Fifth edition. 2010. Hodder Arnold, London, United Kingdom.

  • Robbins and Cotran Pathologic Basis of Disease. V. Kumar, A.K. Abbas, J.C. Aster, 2015, 9th edition, Elsevier, Philadelphia. PA.

  • Versteeg HH et al. New fundamentals in hemostasis. Physiol Rev. 2013; ;93:327-358.

  • Other selected scientific papers and parts of other text books.