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Signal Transduction and Hallmarks of Cancer



Cancer is a complex disease in which mutations in the DNA cause aberrant cellular signaling that ultimately affects critical cell functions. Several hallmarks of cancer have been defined including cell autonomous aberrations affecting survival, proliferation, and metabolism as well as altered communication with multiple cell types in the cancer microenvironment. Together, these hallmarks allow tumors to develop, grow, metastasize, and evade therapies. In this caput program, aberrant signal transduction cascades mediating the hallmarks of cancer are discussed and translation to cancer therapies is highlighted.


Dr. E.H.J. Danen

Admission requirements

Basic knowledge of Cell Biology and Biochemistry.

Mode of instruction

Lectures and paper discussions.

Reading list

  • Albert et al, Molecular Biology of the Cell; Hanahan D and Weinberg RA (2011) Hallmarks of Cancer: The Next Generation. Cell 144:646-674.

  • Papers assigned by teachers

Course objectives

  • Knowledge of the various hallmarks of cancer

  • Knowledge of the signaling pathways in control of these hallmarks of cancer

  • Understanding the complexity of the disease and how this complicates therapies but may also provide new avenues for therapy.

Assessment method

Written Exam, written assignment, active participation.


The course will be given on Wednesdays in March 2019, details to be announced.


Application via uSis. Registration closes 1 month before the start of the course or earlier, when when the maximum number of participants of 48 students is reached.