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A Clinical Pharmacologist Approach to type 2 Diabetes


Description and Course Objectives

For diabetes mellitus (DM), one of the most prevalent chronic disease entities, different pathophysiological mechanisms can be identified. Next to the most common form of type II DM (T2DM), type I diabetes (T1DM), gestational diabetes (GDM) and iatrogenic DM, mainly caused by drug-induced disturbances of glucose homeostasis, can be distinguished. Obviously, therapies to combat DM should be tailored to the underlying pathophysiology . Furthermore, hyperglycemia and other phenomena of DM are risk factors to develop (premature) cardiovascular disease.

In this course, students will learn how to identify key factors in the pathophysiology of diabetes, evaluate currently available compounds related to the underlying pathophysiology, and critically evaluate emerging therapies. To this end, students will learn to assess the value and limitations of animal models and human disease models. In addition to theory, the students will meet patients with diabetes and learn about their difficulty coping with the disease and its sequela. It is expected that the students will develop pharmacology-based ‘solutions’ for the problems that the patients will present to them.

The course will be held at the Centre for Human Drug Research (Zernikedreef 8, Leiden) and will consists of lectures, patient demonstrations, literature reviews and self-study assignments.


Prof. dr. J (Koos) Burggraaf


Students of Bio-Pharmaceutical Sciences.


Adequate knowledge of Pharmacology and (patho-)physiology.
A minimum of 5 students and a maximum of 9 students will be admitted.


Lectures / self study / case-studies.


Will be announced during the lectures.


Presentation, verbal examination and report.


This course is taught every other year between December – February. In 2018 it will be held in the mornings on the following dates: January 10th, 12th, 17th, 19th and 26th.