This course is an elective course for MSc Life Science and Technology and MSc Chemistry students
BSc in MST with a major in Life Science and Technology. Other candidates should have a solid background in molecular and cell biology.
In this course current topics relating to chromatin organization and genome activity across the three domains of life (eukaryotes, archaea and bacteria) will be discussed. Following an overview of basic concepts of chromatin organization in different species, the interplay of chromatin structure with cellular processes will be discussed. Novel techniques for studying these aspects will be highlighted, as well as novel approaches to manipulate chromatin organization with applications in research and medicine.
Topics will be discussed based on recent review and research articles, as well as current research within the research institute.
At the end of the course students:
• Will have an overview of the mechanisms by which chromatin is organized across the domains of life, with emphasis on similarities and differences.
• Will have insight in the effects of chromatin organization on processes occurring in a chromatin context.
• Will have an overview of novel techniques and approaches to study and manipulate chromatin
• Will be able to discuss verbally as well as in writing specific topics related to the content of this course
• Will be able to critically evaluate manuscripts of others and implement feedback in their own manuscripts
• Can digest and present a summary of a scientific article from the literature
Mode of instruction
Lectures, discussions, lab visits
Schedule information can be found on the website of the programmes.
Articles on the topic of each lecture will be provided. Relevant literature for writing of the essay will need to be identified by the students.
Review of essays (30%)