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Genome organization and maintenance in cancer and aging (GCA)

Vak 2017-2018

Genome organization and maintenance in cancer and aging
Up to date schedule information

Core course in MSc Life Science and Technology, elective course MSc Chemistry

Admission

Students with a BSc in LST or MST with Cell Biology
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Description

To understand the molecular bases for cancer and ageing, knowledge of the organization and maintenance of our genomes is of vital importance. The following topics will be dealt with: DNA stability and repair, chromatin structure, post-translational histone modifications, gene regulation, recombination, and chromatin remodelling. The molecular basis for a number of DNA repair syndromes and premature ageing diseases will be explained. Course is based on research papers and in the background the textbook The Cell Alberts, 6 edition
After this course students:
• Will understand the molecular basis of ageing and cancer
• Will have insight in processes involved in DNA repair and chromatin organisation through post-replication and translational modifications
• Will be able to read literature relevant for the above mentioned diseases and processes
• Will be able to subtract conclusions from that literature
Presence at classes is obligatory.

Assessment method

Open book exam, no laptops at examination