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Regulation of the Immune Response in Human Disease


Admission requirements

  • Successful completion of How To Write A Research Proposal is strongly recommended.

  • Lab work experience is required.

  • The course will be given at level 500, expanding on knowledge acquired in the second-year Bachelor's course Immunology.


Period: 4 February 2019 - 1 March 2018

The main theme of this advanced course in immunology is a detailed understanding of the complex interactions between antigen presenting cells and immune effector cells that regulate the immune response. Furthermore, it is expected that biomedical research into the interactions between these cells will lead to new therapies against infectious and immune-mediated diseases. This course will provide detailed insights into the latest developments in fundamental biological research aiming at understanding the complex interactions between antigen presenting cells and immune effector cells as well as into some aspects of today-s clinical practice.


The first week will consist of a refreshment of immunology, immunological debate, journal clubs, extensive literature study (complex reviews) on the roles of antigen presenting cells and immune effector cells and molecules in the four topics (infectious disease, immunotherapy, transplantation, and chronic inflammation), and lectures by an international expert in the field.

In the second week students will choose between two topics, i.e. “infectious diseases” and “chronic inflammation”, and in the third week each student will choose between “transplantation” and “immunotherapy”. During these 2 weeks the students will closely collaborate with an experienced technician and/or PhD student involved in the research lines of choice of the student. This intensive in-lab training period consists of both theoretical and practical work, and the students will become familiar with the various aspects of the scientific research of the postdoc/PhD student.

During this period the student will have familiarised her/himself with the various topics allowing her/him to prepare a research proposal in the field of the topic of choice in the last week. As this assignment is very intensive, student will start with their research proposal in week 2 of this course. In week 4 of the course, students will present their proposal both orally and in writing.

This course will particularly work on:

Research competences:
In-lab training related to a research project, defining a research proposal, writing a research proposal, analyzing data with tutors, choosing appropriate techniques, integrate different biomedical disciplines in the design of a research question, design methods, and implement these new research tools.

Professional competences:
Collaborating with peers, digesting of other people’s opinions, reflecting on personal actions.

Course objectives

The student:

  • Understands the interactions between antigen presenting cells and immune effector cells;

  • Understands the involvement of these cell types in the control of immune responses

  • Understands the involvement of immunological processes in health and disease

  • Understands the current challenges in the field within the topics of choice

  • Understands the different activities of the researchers in the various institutions within the LUMC that are involved in immunological research, by following lectures given by these researchers.

  • Is able to formulate hypotheses regarding these problems, but also prepare an essay including a (small) experimental design to address such a hypothesis

  • Is able to write a research proposal

  • Can design and perform experiments and report the results

  • Is able to assess targets for therapy of infectious and immunological diseases using their knowledge of the

  • relevant various topics

  • Can participate in an immunology debate

  • Can report results from experiemnts

  • Can design and perform experiments


All course and group schedules are published on our LUMC scheduling website or on the LUMC scheduling app.

Mode of instruction

Plenary seminars provided by experts in the field, self study assignments and interactive discussions between tutors and trainees as detailed in the course book, practical work in the form of mini-projects and workgroup discussions by postdoc/PhD students and tutors.

Course load

Total course load is the amount of EC’s multiplied with 28 hours.

Assessment method

Summative assessment:

  • Written research proposal

  • Oral report lab training

  • Oral presentation research proposal

  • Participation (training+discussion)


Blackboard will be used during this course.

Reading list

Will be distributed during the course.


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