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Biomedical imaging

Vak 2018-2019

Admission requirements

Students can enroll for a half minor if they have obtained 60 credits from the first year.

International Students should have an adequate background in Medicine. Admission will be considered based on CV and motivation letter.
For more information, please contact internationalisering@lumc.nl.

Description

During the first part of this half-minor the broad spectrum of diagnostic imaging techniques will be discussed, using clinical examples that show the conditions wherein they are often used. Cardiovascular imaging and CT, neuro imaging and MRI, interventional radiology and ultrasound will, amongst others, be highlighted. In the following weeks, the link between radiology and fields such as oncology, nuclear medicine, pathology and microscopic imaging and image-guided surgery will be emphasized from both a clinical and research perspective.

Course objectives

  1. Evaluate the role of CT- and MRImaging in diagnosis and therapy of patients with cardiovascular, oncologic or neurologic disease;
  2. Define the scope and limitations of the various radiologic modalities (CT, MRI, SPECT, PET, US Fluorescence);
  3. Establish which criteria (medical, physics and costs) are instrumental for the selection of a radiologic examination;
  4. Identify critical steps that need to be taken during preclinical evaluation of novel imaging tracers before these can be clinically applied;
  5. Assess and criticize the application of new clinical imaging research lines, e.g. fluorescence-based imaging, hybrid modalities such as PET-MRI and image guided navigation techniques;
  6. Identify in which clinical situations image guided interventions (cardiological, neurological or oncological), using Ultrasound, CT, Angiography, Nuclear Medicine, and Fluorescence imaging may improve patient care.
  7. Envisage which microscopy/pathology approaches can be applied to analyse the molecular aspects of a disease based on neurological and oncological symptoms.
  8. Evaluate during debates the (potential) value of biomedical imaging in topics of current societal and medical interest, pertinent to LUMC profile areas.
  9. Apply the insight gained in this imaging course to write a well motivated opinion paper on the role of biomedical imaging in one of the LUMC profile areas, while taking practical aspects, cost-effectiveness and risks of this examination for the patient (especially: radiation burden and possible adverse effects of contrast agents) into account;

Timetable

All course and group schedules are published on our LUMC scheduling website or on the LUMC scheduling app.

Mode of instruction

Lectures, workgroups, patient demonstrations, laboratory visits and practicals.

Course load

Total course load is the amount of EC’s multiplied with 28 hours.

Assessment method

Case presentation (5x)
Presentation per student of one or more neuroradiology cases.
Cases have to be prepared in written form (ppt) and have to be handed in. See Schedule.
Passed / Not passed

EXAM-1 (open questions)
Knowledge obtained in week 1-4 will be tested. Mark (1-10) counts for 20% of the final mark. Students will receive their marks before the end of Week 5.

EXAM-2 (open questions)
Knowledge obtained in week (1-4), 5,6,7 will be tested. Mark (1-10) counts for 20% of the final mark. Students will receive their marks before the end of Week 8.
To make sure all results are criticized equally, the coordinators will alternate between both exams. Debriefing is included immediately after the exams;

Debate on the use of biomedical imaging in clinical routine and research:
Discussion in a group of 5 students on the role of biomedical imaging in one of the LUMC profile areas.
Mark (1-10) counts for 20% of the final mark.

Written report:
Prepare a report/opinion paper of 3000-4000 words (including a Literature Review) on the role of biomedical imaging for a specific topic related to the debate in which the student participates. Should be handed in on Friday in week 10. To make sure all papers are criticized equally, a minimum of two coordinators will give a mark. Students will be informed on their mark (40% of final mark) by the end of week 11. The assessment criteria for this report are described in a Rubik format, which is included in the module book. Study load of the report is one week.
Students will be informed about their final mark within 3 weeks after the end of the course.

**Examination committee: **
A.R. van Erkel (MD. PhD), F.W.B. van Leeuwen (PhD), T. Buckle (PhD), J. Doornbos (PhD)

Examination dates:
The exam dates can be found on the schedule website.

Blackboard

Blackboard will be used during this course.

Reading list

Papers will be provided per week via Blackboard.

The following websites give a fair impression of the topics covered in this half minor:

General radiology
http://www.med-ed.virginia.edu/courses/rad Virginia University
http://eradiology.bidmc.harvard.edu/
http://www.radiologyeducation.com

CT
http://www.ctisus.com/ CT-anatomy, Protocols, Teaching files, etc
http://en.wikipedia.org/wiki/Virtual_colonoscopy CT colonography

Ultrasound
http://en.wikipedia.org/wiki/Ultrasound_imaging Basics of ultrasound
http://en.wikipedia.org/wiki/Obstetric_ultrasonography

MRI
https://www.imaios.com/en/e-Courses/e-MRI basics
http://en.wikipedia.org/wiki/Mri
http://www.cis.rit.edu/htbooks/mri/ basic physics
http://en.wikipedia.org/wiki/Functional_magnetic_resonance_imaging fMRI
http://en.wikipedia.org/wiki/Statistical_parametric_mapping fMRI

Nuclear Medicine
http://www.radiologyinfo.org/en/info.cfm?PG=gennuclear
http://www.snmmi.org/AboutSNMMI/Content.aspx?ItemNumber=6433 What is Nuclear Medicine
http://en.wikipedia.org/wiki/Pet_scan What is PET

Image Guided Surgery
http://en.wikipedia.org/wiki/Fluorescence_image-guided_surgery

Mass spectrometry Imaging
http://en.wikipedia.org/wiki/Mass_spectrometry_imaging
http://www.maldi-msi.org/ MALDI

Micro-MRI (mouse atlas) preclinical imaging
http://www.emouseatlas.org/emap/home.html

Microscopy: for fundamentals of Light Microscopy, see
http://en.wikipedia.org/wiki/Microscopy
http://en.wikipedia.org/wiki/Fluorescence_recovery_after_photobleaching
http://en.wikipedia.org/wiki/Förster_resonance_energy_transfer

Electron Microscopy
http://en.wikipedia.org/wiki/Electron_microscopy

Allen Brain Atlas
http://www.brain-map.org/
http://www.brainscope.nl (use Chrome browser)

Registration

Students are required to register for exams through uSis. The registration for a working group is done by handing in your ‘studieplan’.

Contact

Joost Doornbos
Radiology
J.Doornbos@lumc.nl