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Synthetic Organic Chemistry



Strategies for the synthesis of current and newly developed drugs are discussed, including the mechanisms of reactions, functional group transformations, the use of protective groups, control of regio-, chemo- and stereoselectivity.

Course Objectives

After the course students:

  • Will have knowledge of the relation of structure and reactivity of organic molecules;

  • Will have knowledge of the mechanisms of standard chemical reactions, with a focus on functional group conversions;

  • Will have knowledge of chemical concepts such as, acidity, basicity, delocalization, conjugation, aromaticity, stereochemistry, tautomerism, regio-, chemo- and stereoselectivity.

  • Will be able to apply the chemical concepts;

  • Will be able to predict the structures of products of standard reactions;

  • Will be able to predict the required reagents for standard reactions;

  • Will be able to describe the mechanism of reactions.

Reading list

  • Organic chemistry, Clayden, Greeves, Warren, Oxford University

  • Literature will be provided during the course.


Dhr. Prof. Dr. G.A. van der Marel

Mode of instruction

Lectures with active participation of the student

Assessment method

Written exam

Admission requirements & Registration

This course is mandatory for students who do the Minor ‘Modern Drug Discovery’ (MDD) and these students will be given priority. Additional places may be available to students outside the minor under the condition that they meet the admission criteria. The same admission criteria apply to this course as for the entire Minor MDD. Application for students outside the Minor MDD occurs via the study advisers of Bio-Pharmaceutical Sciences, LST or MST.