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Cell Signaling in Cancer and Drug Safety



Research projects within the Course ‘Cell Signaling in Cancer and Drug Safety’ (CS-CDS) mainly focus on molecular signal transduction and on pathways/networks in drug toxicity & safety, cancer progression and cancer drug resistance. Imaging and computational modeling play an important role in the context of monitoring cellular behavior at multiple scales. All research projects are studied at the LACDR division of Toxicology (part of the cluster Drug & Target Discovery). Computational projects are available for students who have followed Part 1 of the Minor ‘Computational Approaches to Disease, Signaling and Drug Targets’.

Course objectives

The objective of the course is to train students with diverse practical skills in molecular and cellular biology or in computational skills in biomedicine, particularly in the context of cancer, drug safety and therapeutics. Students will be trained in research design and planning.


Mw. Dr. A. van Oosten

Mode of instruction

The course will consist of preparing and conducting a 2-week practical or computational research project, followed by reporting. Students will be supervised by individual PhD students or postdoctoral researchers.

Assessment method

  • First research presentation (research design): 10%

  • Final research presentation (research results): 15%

  • Practical/computational skills: 40%

  • Research report: 35%

Admission requirements & Registration

This course is mandatory for and restricted to students who follow the Elective Module DSDT. Furthermore, a maximum of 10 additional computational instead of practical projects are available for students who follow the minor ‘Computational Approaches to Disease Signaling and Drug Targets’ (CADSDT). In case more than 10 of the latter students apply for a computational project, students will be selected based on a motivation letter. Moreover, students are only admitted to a computational project if they have actively participated in the Course 'Computational Biomedical Research' of said minor. All students that are admitted to the Elective Module DSDT or a computational project for the Minor CADSDT will be registered for this course in uSis by the Minor coordinator.