In order to systematically investigate biological systems, experimental and computational approaches can be combined. To understand a biological system, structural and dynamic properties can be represented in a computational model describing the entities involved and their interactions. This course aims at making students aware of formal and mathematically precise approaches to the faithful modeling of biological processes. In an interdisciplinary approach we will investigate how to construct and analyze such formal models using the framework of Petri nets. Biological case studies will be used as a guide to the modelling of biological phenomena.
This course is a combination of lectures, seminar sessions, and project work. After the introductory lectures and some practical sessions on using Petri Net tools, groups will be formed to work on a project to model aspects of a given biological process using Petri nets. Knowledge of Biology (the case studies) or Computer Science (Petri Nets) is not a prerequisite. Presence at all meetings is mandatory. Note that there will be a maximum to the number of students that can participate; there will be a confirmation of enrollment at the second meeting.
becoming acquainted with uses of modelling techniques for biological research;
gaining theoretical knowledge of the modelling framework of Petri nets;
being able to abstract complex biological process to a structured model.
The most recent timetable can be found at the students' website.
Mode of instruction
Online seminar sessions
Online presentation of own work (including a written report following a template)
Hours of study: 168 (= 6 EC)
Literature research: 26
Presentation and preparations: 26
Practical work: 30
Grading is based on:
presence and active participation (10%)
participation in discussions within the group of relevant literature (10%)
contribution to a project: modeling, presentation, report (80%)
The final mark is the weighted average of the above as indicated, but under the addional condition that both the result for the first 20% and the result for the last 80% are sufficient (at least 5.5).
Modeling in Systems Biology – The Petri Net Approach.
Additional materials that will be announced during the course.
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