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Genome organization and maintenance in cancer and aging (GCA)


Admission requirements

Elective course in MSc Chemistry & MSc Life Science and Technology
For students with a BSc in LST or MST with Cell Biology or equivalent


To understand the molecular bases for cancer and ageing, knowledge of the organization and maintenance of our genomes is of vital importance. The following topics will be dealt with: DNA stability and repair, chromatin structure, post-translational histone modifications, gene regulation, recombination, and chromatin remodelling. The molecular basis for a number of DNA repair syndromes and premature ageing diseases will be explained.

Course objectives

After this course students

  • Will understand the molecular basis of ageing and cancer

  • Will have insight in processes involved in DNA repair and chromatin organisation through post-replication and translational modifications

  • Will be able to read literature relevant for the above-mentioned diseases and processes

  • Will be able to subtract conclusions from that literature


Schedule information can be found on the website of the programmes

Mode of instruction


Assessment method

Open book exam, no laptops at examination.
Presence at classes is obligatory.

Reading list

Course is based on research papers and in the background the textbook The Cell Alberts, 6 edition.


Register for this course via uSis


Prof. Dr. J. Brouwer


According to OER article 4.8, students are entitled to view their marked examination for a period of 30 days following the publication of the results of a written examination. Students should contact the lecturer to make an appointment for such an inspection session.