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Physiology, Advanced Concepts


Admission requirements

The course Physiology, Advanced Concepts, is meant for the student who has already followed the course Physiology, Basic Concepts, or has a comparable level of knowledge on cardiovascular, respiratory and renal physiology.


This course focuses on impaired circulation as a result of inflammation, sepsis, endothelial dysfunction, thrombosis, atherosclerosis and vascular remodelling and its consequences for heart, lung and kidney physiology. Subtopics that will be discussed during the course are:

  • endothelial (dys)function

  • (ab)normal hemostasis

  • sepsis

  • vascular responses to Toll-like receptor activation

  • inflammatory & ischemic kidney disease

  • pulmonary arterial hypertension

  • atherosclerosis, coronary artery disease & myocardial infarction

  • heart failure: hemodynamic & electrophysiological effects

Course objectives

After having followed this course, students should have a clear understanding of the major pathophysiological processes involved in blood flow impairment and its consequences for heart, lung and kidney function.


All course and group schedules are published on our LUMC scheduling website or on the LUMC scheduling app.

Mode of instruction

This course consists of lectures, seminars, working groups and self-study assignments.

Assessment method

Written exam.

Reading list

  • Medical Physiology, Boron W & Boulpaep E, eds., 3rd edition, 2016, Elsevier, Philadelphia. PA.

  • Levick's Introduction to Cardiovascular Physiology, Herring H & Paterson DJ, eds., 6th edition, 2018. CRC Press, Boca Raton, FL.

  • Robbins and Cotran Pathologic Basis of Disease. Kumar V, Abbas AK, Aster JC, eds., 9th edition, 2015, Elsevier, Philadelphia. PA.

  • Versteeg HH et al. New fundamentals in hemostasis. Physiol Rev. 2013;93:327-358.

  • Other selected scientific papers and parts of other text books.


To participate in workgroups and exams students must register with uSis.