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Medicinal Chemistry & Drug Discovery (MCDD)


Admission requirements

Core course MSc Chemistry – Chemical Biology, elective course MSc Life Science and Technology.
For students with a BSc in MST, LST or equivalent. Students should have basic knowledge of protein structure as well as knowledge of organic chemistry at the level of Molecular Chemistry (4423MCHEM) or Synthetic Organic Chemistry (4012SOCH5).
This course was previously given under the name Advanced Medicinal Chemistry (AMC), uSis code 4423ADMC6. This course cannot be combined with AMC in a programme.


The course introduces the students to the theory and methods of medicinal chemistry and its role in drug discovery.

Course objectives

The aims are:

  • to raise students’ interest & enthusiasm for the field of medicinal chemistry & drug discovery.

  • to give an introduction of the most important concepts and methods used in rational drug design and their application in drug discovery in relation to (molecular) pharmacology, toxicology and structural biology.

  • to give the student sufficient background to interpret structure-activity relationships and fundamental principles governing the molecular interactions of a drug with its target.

  • to introduce the latest developments and insights in the field of medicinal chemistry & drug discovery.

  • to allow students to solve problems that are rooted the biological domain with chemical tools, which are found and optimized through a medicinal chemistry approach.


Schedule information can be found on the website of the programmes. Assignment deadlines are communicated via Brightspace.

Mode of instruction

Flipped classroom: online lectures with discussions and assignments in (virtual) class room.

Assessment method

Written exam

Reading list

Basic Principles of Drug Discovery and Development, Benjamin E. Blass ISBN 978-0-12-411508-8, 1st print.


Register for this course via uSis


Prof.dr. Mario van der Stelt, Prof.dr. Stan van Boeckel and Dr. Anthe Janssen


A laptop is required for the tutorials.

According to OER article 4.8, students are entitled to view their marked examination for a period of 30 days following the publication of the results of a written examination. The date, time and location of an inspection session will be announced on Brightspace.