Core course in MSc Life Science and Technology, elective course MSc Chemistry.
Students are expected to have knowledge of fundamental concepts in molecular biology, such as the central dogma and the relationships between sequence, structure and function of proteins. Experience in programming is not required.
This course is about bioinformatics approaches to omics data analysis in human health and disease.
It will cover
a) bioinformatics data resources (global data sharing for omics data)
b) computational analyses of genomic data (genome sequencing approaches, genome assembly, de novo sequencing, resequencing and variation analysis),
c) computational analyses of transcriptome and proteome data (RNA-Seq and microarray analyses, RNOmics, pathway analysis, functional enrichment/over-representation and protein-protein interaction networks)
d) medical informatics (omics in rare and complex disease studies, principles and problems in managing and sharing patient data)
At the end of the course students
will have knowledge of fundamental principles in bioinformatics
will understand biomedical applications of bioinformatics analyses
will be able to analyse a range of omics data using bioinformatics tools
will understand the impact of the omics revolution on biomedical informatics research
Schedule information can be found on the website of the programmes. Assignment deadlines are communicated via Brightspace.
Mode of instruction
Lectures, practical classes, literature discussion and assignments
Written examination (50%) and assignments (50%)
If the corona restrictions preclude an on-campus written examination, the final examination will be a time-limited online essay. Such changes to the assessment method are announced via Brightspace a minimum of 10 working days before the originally scheduled exam date.
Practical exercises and online discussions contain material that may be included in the examination.
Bioinformatics and Functional Genomics, Jonathan Pevsner, publisher John Wiley & Sons Inc, 3rd edition. ISBN: 978-1-118-58178-0
Bioinformatics and Functional Genomics online supplement
Current bioinformatics literature referenced in the lectures and practical sessions
Register for this course via uSis
Students need to make use of their own laptop running Windows, Linux or Macintosh operating system for the computer exercises.
According to OER article 4.8, students are entitled to view their marked examination for a period of 30 days following the publication of the results of a written examination. Students should contact the lecturer to make an appointment for such an inspection session.