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Cross-domain chromatin organisation (CDC)


Admission requirements

This course is an elective course for MSc Life Science and Technology and MSc Chemistry students
Suitable for students with a BSc in MST or LST. Other candidates should have a solid background in molecular and cell biology.


In this course current topics relating to chromatin organization and genome activity across the three domains of life (eukaryotes, archaea and bacteria) will be discussed. Following an overview of basic concepts of chromatin organization in different species, the interplay of chromatin structure with cellular processes will be discussed. Novel techniques for studying these aspects will be highlighted, as well as novel approaches to manipulate chromatin organization with applications in research and medicine.

Topics will be discussed based on recent review and research articles, as well as current research within the research institute.

Course objectives

At the end of the course students:

  • Will have an overview of the mechanisms by which chromatin is organized across the domains of life, with emphasis on similarities and differences.

  • Will have insight in the effects of chromatin organization on processes occurring in a chromatin context.

  • Will have an overview of novel techniques and approaches to study and manipulate chromatin

  • Will be able to discuss verbally as well as in writing specific topics related to the content of this course

  • Will be able to critically evaluate manuscripts of others and implement feedback in their own manuscripts

  • Can digest and present a summary of a scientific article from the literature


Schedule information can be found on the website of the programmes. Assignment deadlines are communicated via Brightspace

Mode of instruction

Lectures, discussions, lab visits
Lectures and student presentations may be held online if necessitated by corona measures. In such situation lab visits will be cancelled.

Assessment method

Essay (50%)
Presentation (20%)
Review of essays (30%)
Participation in the reviewing of essays and attendance at presentations is obligatory.
Changes to the assessment method will be announced via Brightspace a minimum of 10 working days before the originally scheduled deadline.

Reading list

Articles on the topic of each lecture will be provided via Brightspace. Relevant literature for writing of the essay will need to be identified by the students.


Register for this course via uSis


Remus Dame


According to OER article 4.8, students are entitled to view their marked examination for a period of 30 days following the publication of the results of a written examination. Students should contact the lecturer to make an appointment for such an inspection session.