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In-vivo biomolecular interactions underlying diseases (IBID)


Admission requirements

Core course in MSc Life Science and Technology, elective course MSc Chemistry.
For students with a BSc LST or equivalent, or for students who have passed Molecular Cell Biology (4423MOLCB) in 2020-21 or Cell Biology (4423CELBI) and Molecular Biology (4423MOLBI) in earlier years.


Studies of in-vivo bio-molecular interactions are essential for our understanding of cellular functioning. Specific in-vivo interactions controlling different aspects of cellular function and physiology will be discussed in normal, healthy and disease-related, situations. A strong emphasis will also lie on chemical biology aspects of lysosomal storage diseases. Academic skills of writing, reading scientific articles and giving presentations are included.

Course objectives

At the end of the course students:

  • Will have in depth understanding of fundamental cell and molecular biology aspects of normal cell situations.

  • Will have in depth knowledge of fundamental principles of bio-molecular interactions underlying diseases and understanding of drug target finding relevant for developing novel drugs

  • Will have knowledge of the societal impact of cell biology for curing world-wide threatening diseases, such as lysosomal storage and other neurological diseases.

  • Can digest a scientific article from the literature, including details on how to perform research in relation to molecular pathways.

  • Will be able to write scientific mini-reviews based on recent cell biology/disease literature.

  • Will be able to present orally recent cell-biology/disease related literature

  • Will be able to understand the current disease-related cell biology literature that was not discussed


Schedule information can be found on the website of the programmes. Assignment deadlines are communicated via Brightspace.

Mode of instruction

Lectures and instructions in scientific writing

Assessment method

Writing scientific essays (60%) and an oral presentation (40%)

Reading list

The course is based on recent articles, either review or research papers relevant for modern cell biology/molecular disease studies and papers of on-going related research in the LIC and in cooperating institutes
Slides presented during the courses


Register for this course via uSis


Prof.dr. Hans Aerts, Dr. Rolf Boot