Admission requirements
The course Physiology, Advanced Concepts, is meant for the student who has already followed the course Physiology, Basic Concepts, or has a comparable level of knowledge on cardiovascular, respiratory and renal physiology.
Description
This course focuses on impaired circulation as a result of inflammation, sepsis, endothelial dysfunction, thrombosis, atherosclerosis and vascular remodelling and its consequences for heart, lung and kidney physiology. Subtopics that will be discussed during the course are:
endothelial (dys)function
(ab)normal hemostasis
sepsis
vascular responses to Toll-like receptor activation
inflammatory & ischemic kidney disease
pulmonary arterial hypertension
atherosclerosis, coronary artery disease & myocardial infarction
heart failure: hemodynamic & electrophysiological effects
Course objectives
After having followed this course, students should have a clear understanding of the major pathophysiological processes involved in blood flow impairment and its consequences for heart, lung and kidney function.
Timetable
Between semesters, we will transfer from using the scheduling app to using MyTimeTable: all educational activities before 6 February 2023 can be viewed on our LUMC scheduling website or in the scheduling app. View MyTimeTable for your schedule from 6 February onwards.
Mode of instruction
This course consists of lectures, seminars, working groups and self-study assignments.
Assessment method
Written exam.
Reading list
Medical Physiology, Boron W & Boulpaep E, eds., 3rd edition, 2016, Elsevier, Philadelphia. PA.
Levick's Introduction to Cardiovascular Physiology, Herring H & Paterson DJ, eds., 6th edition, 2018. CRC Press, Boca Raton, FL.
Robbins and Cotran Pathologic Basis of Disease. Kumar V, Abbas AK, Aster JC, eds., 9th edition, 2015, Elsevier, Philadelphia. PA.
Versteeg HH et al. New fundamentals in hemostasis. Physiol Rev. 2013;93:327-358.
Other selected scientific papers and parts of other text books.
Registration
Registration must be done via MyStudyMap. Registration in MyStudyMap gives you automatic access to the course in Brightspace. For more information, please visit the Leiden University website for students.