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Magnetic Resonance Phenomena


Admission Requirements

Introduction to quantum mechanics. Please get in touch with the teacher if not applicable to your case.

Programming basics are preferable, but not a must.

Students from chemistry, mathematics, astronomy and engineering are also welcome to attend the course.


The course will describe the quantum mechanical and semi-classical formulation of nuclear magnetic resonance and magnetic resonance imaging, together with their biomedical applications and the hardware needed to perform these experiments.
The course will consist of lectures where specific topics will be presented; exercises solved in the classroom; and ad-hoc sessions in which scientific papers will be discussed/presented by groups of students (i.e. a journal club).
Specific covered topics are:

  • NMR basics: energy levels, quantum mechanics formalism of magnetic resonance, precession, RF pulses, relaxation, chemical shift, one- and two-dimensional NMR spectroscopy

  • MRI basics: k-space, imaging sequences, image contrast, T1- and T2-weighted sequences, instrumentation

  • Advanced MRI: fast imaging, angiography, lipid suppression, localized spectroscopy, diffusion and perfusion.

Course objectives

After completing the course, you will be able to:

  • identify the physical principles behind NMR spectra appearance

  • apply the concept of T1 or T2 recovery/decay to a practical situation

  • apply the product operator formalism to the time-evolution of the magnetization during a complex pulse sequence

  • take an informed decision on how to proceed with an experiment based on a given data quality

  • identify and analyze and the sources of image contrast in an MRI image

Transferable Skills

  • You will need to prepare for lectures ahead, by studying the lecture material and solving quizzes and assignments given by the instructor

  • You will be scoring previous-years exams and discuss the grade with a peer

  • During the journal club, you will present and discuss a research paper in front of the classroom


See Timetable in BrightspaceSchedule
For detailed information go to Timetable in Brightspace

You will find the timetables for all courses and degree programmes of Leiden University in the tool MyTimetable (login). Any teaching activities that you have sucessfully registered for in MyStudyMap will automatically be displayed in MyTimeTable. Any timetables that you add manually, will be saved and automatically displayed the next time you sign in.

MyTimetable allows you to integrate your timetable with your calendar apps such as Outlook, Google Calendar, Apple Calendar and other calendar apps on your smartphone. Any timetable changes will be automatically synced with your calendar. If you wish, you can also receive an email notification of the change. You can turn notifications on in ‘Settings’ (after login).

For more information, watch the video or go the the 'help-page' in MyTimetable. Please note: Joint Degree students Leiden/Delft have to merge their two different timetables into one. This video explains how to do this.

Mode of instruction

See Brightspace

Assessment method

The final exam consists of open-ended and multiple-choice questions (95% of the total grade). The assessment matrix of the exam will be made available during the course.

Additional grade (up to 5%) based on journal club. The rubric of the journal club will be made avaialble during the course.

If required, the exam may be re-taken.

Reading list

Magnetic Resonance Imaging: Physical Principles and Sequence Design,
Second Edition
Author(s): Robert W. Brown Ph.D., Yu‐Chung N. Cheng Ph.D., E. Mark Haacke Ph.D., Michael R. Thompson Ph.D., Ramesh Venkatesan D.Sc., First published:22 April 2014 Print ISBN:9780471720850 |Online ISBN:9781118633953 |DOI:10.1002/9781118633953 © 2014 John Wiley & Sons, Inc.

Text available at the library (online format)


From the academic year 2022-2023 on every student has to register for courses with the new enrollment tool MyStudyMap. There are two registration periods per year: registration for the fall semester opens in July and registration for the spring semester opens in December. Please see this page for more information.

Please note that it is compulsory to both preregister and confirm your participation for every exam and retake. Not being registered for a course means that you are not allowed to participate in the final exam of the course. Confirming your exam participation is possible until ten days before the exam.
Extensive FAQ's on MyStudymap can be found here.


The course is offered by teachers of the Gorter-centre for High Field MRI (LUMC).
Instructor: T.H. Oosterkamp