Admission requirements
Elective course in MSc Life Science and Technology, MSc Chemistry.
Students with a BSc degree in LST, MST, or BSc degree in Biology/Chemistry or equivalent can enroll in this course.
A 5 EC version of this course was previously given in the minor programme Advanced LST (course code 4604L2811). This course cannot be taken if this version was included in the BSc programme.
Previous versions of this course (course codes 4423QILSC and 4423QILS4) cannot be combined with this course in the final examination.
Description
The course on “Quantitative MRI in Disease Diagnosis” aims to provide an understanding of basic principles of magnetic resonance imaging (MRI) and its quantitative applications to characterize biological tissues in vitro and in vivo, with a specific focus on identifying biomarkers for disease diagnosis through the use of structural and functional MRI. The course will cover topics such as nuclear magnetism, longitudinal and transverse relaxation, MR angiography, diffusion, functional imaging and MR spectroscopy. The course will also cover current research articles related to these topics.
Course objectives
At the end of the course students should be able to:
explain concepts of nuclear relaxation mechanism in biological tissue.
understand how to achieve image formation from MR signal (the concept of spatial encoding) and MRI pulse sequence design.
understand concept and applications of anatomical imaging by exploiting longitudinal, transverse relaxation phenomenon and state-of-the art of quantification using multicomponent analysis.
can explain how smart MRI contrast agents work and their application in disease diagnosis.
understand resting state- and task specific functional MRI.
can explain how diffusion MRI works for quantitative diagnosis.
can apply in vivo localized MR spectroscopy and chemical shift imaging and their application for finding disease biomarkers.
understand how basic MRI experiments are performed on an ultrahigh-field NMR spectrometer.
can summarise and analyse relevant literature in an academic presentation and written literature discussion.
Timetable
Schedule information can be found on the website of the programmes.
In MyTimetable, you can find all course and programme schedules, allowing you to create your personal timetable. Activities for which you have enrolled via MyStudyMap will automatically appear in your timetable.
Additionally, you can easily link MyTimetable to a calendar app on your phone, and schedule changes will be automatically updated in your calendar. You can also choose to receive email notifications about schedule changes. You can enable notifications in Settings after logging in.
Questions? Watch the video, read the instructions, or contact the ISSC helpdesk.
Note: Joint Degree students from Leiden/Delft need to combine information from both the Leiden and Delft MyTimetables to see a complete schedule. This video explains how to do it.
Mode of Instruction
The course will be taught through a series of lectures/lecture videos followed by a tutorial session composed of discussion of recent research articles on the relevant topic and testing with a set of questions to be made each week.
Assessment method
Written exam (70%) and a presentation on a relevant literature paper (30%).
Attendance with active participation at tutorial sessions is mandatory.
Reading list
The following books are recommended:
a) “The Basics of MRI”, Joseph P. Hornak (online: http://www.cis.rit.edu/htbooks/mri/)
b) “MRI Basic Principles and Applications" by Brian M. Dale, Mark A. Brown, Richard C. Semelka, Edition: 5; ISBN: 1119013054
Slides/videos presented during the courses
Articles discussed and cited during the course
Registration
As a student, you are responsible for enrolling on time through MyStudyMap.
In this short video, you can see step-by-step how to enrol for courses in MyStudyMap.
Extensive information about the operation of MyStudyMap can be found here.
There are two enrolment periods per year:
Enrolment for the fall opens in July
Enrolment for the spring opens in December
See this page for more information about deadlines and enrolling for courses and exams.
Note:
It is mandatory to enrol for all activities of a course that you are going to follow.
Your enrolment is only complete when you submit your course planning in the ‘Ready for enrolment’ tab by clicking ‘Send’.
Not being enrolled for an exam/resit means that you are not allowed to participate in the exam/resit.
Contact
Remarks
Assignment and presentation deadlines are communicated via Brightspace.
Software
Starting from the 2024/2025 academic year, the Faculty of Science will use the software distribution platform Academic Software. Through this platform, you can access the software needed for specific courses in your studies. For some software, your laptop must meet certain system requirements, which will be specified with the software. It is important to install the software before the start of the course. More information about the laptop requirements can be found on the student website.