Admission requirements
Students of Bio-Pharmaceutical Sciences, and external students enrolled in a biomedical master program, with adequate knowledge of pharmacology and pharmacokinetics-pharmacodynamics, and statistics.
Description
This lecture series will provide an overview of drug development and therapy optimization strategies for infectious disease therapeutics. Infectious diseases covered include bacterial, fungal, and viral pathogens. We will discuss key preclinical infection models, pharmacokinetic and pharmacodynamic properties of anti-infective agents, translational and clinical development strategies, and personalized medicine of anti-infective agents. Both classical antimicrobial therapeutics as well as novel therapeutic modalities will be covered. The lectures will include both basic concepts as well as specific case studies.
Course objectives
Recall the fundamental theory of pharmacokinetics, pharmacodynamics, pharmacology, and corresponding use of mathematical/statistical modeling.
Obtain understanding of the mode of action of common anti-infective agents against major pathogens.
Obtain understanding of the pharmacokinetic and pharmacodynamic properties of anti-infectives.
Obtain understanding of how the pharmacokinetic and pharmacodynamic indexes are applied to the clinical setting.
Develop understanding of the use of advanced experimental infection models in drug development and their translational potential to the clinic.
Obtain understanding of the use of mathematical modelling in anti-infective drug development and therapy optimization.
Timetable
This course is scheduled in semester 2, period 3.
You will find the timetables for all courses and degree programmes of Leiden University in the tool MyTimetable (login). Any teaching activities that you have sucessfully registered for in MyStudymap will automatically be displayed in MyTimetable. Any timetables that you add manually, will be saved and automatically displayed the next time you sign in.
MyTimetable allows you to integrate your timetable with your calendar apps such as Outlook, Google Calendar, Apple Calendar and other calendar apps on your smartphone. Any timetable changes will be automatically synced with your calendar. If you wish, you can also receive an email notification of the change. You can turn notifications on in ‘Settings’ (after login).
For more information, watch the video or go to the 'help-page' in MyTimetable. Please note: Joint Degree students Leiden/Delft have to merge their two different timetables into one. This video explains how to do this.
A detailed schedule of the course will be published on the Brightspace course module.
Mode of instruction
The course will consist of lectures. Active participation in the discussions and self-study skills are required for this course.
Assessment method
Written Exam (100%)
For each individual exam, the grade is expressed either with pass or fail, or by using a decimal integer between 1.0 and 10.0 that should be ≥ 5.5. The final grade is expressed using an integer between 1 and 10 and can be rounded off/up to a half integer, with the exception of the grade 5.5. Final grades between 5.50 and 5.99 will be rounded up to 6.0. The final grade should be 6.0 to successfully complete this course.
The time and manner of the inspection and of the feedback session on the examination are specified in the Brightspace module of the course.
Reading list
Will be announced during the course.
Registration
Every student has to register for courses with the enrolment tool MyStudymap. There are two registration periods per year: registration for the fall semester opens in July and registration for the spring semester opens in December. Please see this page for more information.
Please note that it is compulsory to register for every exam and retake. Not being registered for a course means that you are not allowed to participate in the final exam of the course. If you want to retake the exam of the course without following the lectures, you have to contact the coordinator of the course to see if this is possible (you would have passed the other assignments of the course in the earlier year).
Registration for your (resit) exam participation is possible until ten days before the exam.
Extensive FAQ's on MyStudymap can be found here.
Contact
Coordinators: Dr. A. Märtson, Prof. J.G.C. van Hasselt, Dr. R.C. van Wijk
Märtson, A. (Anne-Grete) a.martson@lacdr.leidenuniv.nl
Hasselt, J.G.C. van (Coen) coen.vanhasselt@lacdr.leidenuniv.nl
Wijk, R.C. van (Rob) r.c.van.wijk@lacdr.leidenuniv.nl
Remarks
A minimum of 10 participants is required, with a maximum of 40 students. Placement is based on the registration date.
This information is without prejudice. Alterations can be made for next year.