Due to the Corona virus it is unclear how the programmes will take place. For the latest news please check the course page in Blackboard/Brightspace.

# Statistics, modelling and bioinformatics

Course
2012-2013

At least some courses in basic statistics, basic probability and basic mathematics at bachelor level.

## Contact information

Coordinator: Dhr Dr. H.G.J. van Mil
Email: h.g.j.van.mil@umail.leidenuniv.nl

## Description

The course consists of two parts. The first part (Statistics and Modelling) is obligatory for both EBC and MCB students and discusses probabilistic theory, statistical analysis and statistical modelling. After introducing the leading concepts from probability theory its consequences are discussed for measurements and data-analysis in the life sciences; experimental design, power and data simulation are discussed in more detail thereby introducing the concept of a model. More advanced statistical methods are presented to deal with data that cannot be analyzed using standard classical methods.

The second part (Bioinformatics) is only obligatory for MCB students and will focus first on the systemic part of the modeling relationship using a system theoretic perspective of graph theory, control theory and deterministic simulations in dealing with the complexity of the subject matter. Finally, both system theoretic and the statistical methods, are combined in the analysis of high dimensional data, e.g micro arrays, and bioinformatics.

## Learning goals

Course objectives:
To understand the probabilistic nature of life processes and its consequences for the life sciences. The mastery of the methods used to analyze both statistical and deterministic part.

Final qualifications:

• To design experiments taking into consideration elements of experimental design.

• To independently design a strategy for analyzing the data both qualitatively and quantitatively.

• To extent analysis of the deterministic part of the statistical models and to interpret these models from a system theoretic perspective.

• Reflect on some of the normative issues concerning complex systems.

## Timetable

9:00-15:30. Timetable may chance and will be communicated through blackboard.

## Mode of instruction

Lectures, assignments. Some lectures must be prepared by the students with the use of weblectures and tutorials.

## Assessment method

Both part one (Statistics and Modelling) and two (Bioinformatics) have written exams. Part two also contains a graded assignment.

## Blackboard

Lecture, assignments and course blog.