Part 1. Transdermal drug delivery
In this series of lectures several aspects of the skin barrier formation will be discussed in order to obtain insight in the structure and function of the skin. Normal skin as well as diseased skin will be evaluated. After this general introduction we will focus on the various delivery methods that are currently available and their applicability to several groups of drugs. In addition, the penetration routes of drugs and the interaction between the formulations and the skin will be discussed. Studies performed in vitro as well as in vivo will be included.
Part 2. Vaccines
Vaccines are among the most used and most cost effective biopharmaceuticals. They are also the most atypical with regard to their composition (whole pathogen to synthetic peptide), target group (healthy people) and effectiveness (2 – 4 doses protect). In this course insight will be provided in the basics of vaccinology with emphasis on the pharmaceutical aspects. These include – vaccine delivery: immune modulators and delivery vehicles – formulation: stabilisation, immunisation routes, needle free administration – analytics: immunogenicity testing, systems vaccinology, protein characterisation techniques.
Coordinator
Prof. dr. J.A. Bouwstra
Doelgroep
students Bio-Pharmaceutical Sciences.
Toegangseisen
Drug Delivery Technology (300 level course 3rd year of bachelor study BFW, with the Dutch name Geneesmiddelformulering) or Interventies door geneesmiddeltoediening (course of minor Systems Pharmacology).
Onderwijsvorm
Combination of lectures, student presentations, and discussions.
Literatuur
Will be handed out during the course.
Toetsing
Written and/or oral exam.
Doorgang
At least 5 participants.
Rooster
The lecture series Drug Delivery will be taught from 12—23 May, 2014. See roster for details.
Inschrijving
Application via uSis.
Doelstelling
To broaden the knowledge of drug administration via the skin and advanced visualization methods used; to gain basic insight into several aspects of the delivery of protein drugs.