How drugs exert their effects in the body depends on various interactions of drugs with biological systems. On the one hand these consist of interactions that determine the drug concentration in the body: absorption, distribution, metabolism and excretion. On the other hand these are interactions that determine drug effects: binding to target proteins and induction of transduction mechanisms.
The goal of this course is to introduce the basics of integrated pharmacokinetic-pharmacodynamic (PK-PD) system analysis and how it can be applied in the design and development of new drugs.
Integrated PK-PD models describe specific processes occurring between drug administration and drug effects. Modelling will be applied to the transport of drugs to the location in the body where they exert their effect, the binding and activation of target proteins and the activation of the transduction mechanisms (including homeostatic regulatory mechanisms) that determine the course of the drug effects. Finally, drug effects on disease processes and disease progression will be studied.
Prof. Dr. M. Danhof and Dr. E. Krekels
Further information will follow on the Blackboard module of this Course
This course is mandatory for students who do the Minor ‘Disease Signaling and Drug Targets’ (DSDT) and these students will be given priority. Ten additional places are available to students outside the minor under the condition that they meet the admission criteria. The same admission criteria apply to this course as for the entire Minor DSDT. Application for students outside the Minor DSDT occurs via the study advisers of Bio-Pharmaceutical Sciences only.