Period October 19 – November 6, 2015
Clinical pharmacology is the study of drugs in humans. It is underpinned by the basic science of pharmacology, with added focus on the application of pharmacological principles and methods in the real world (from R&D to patient care). The discipline is heavily involved in the research, development an application of (new) medicines. Over the last two decades the discipline has evolved considerably due to a couple of simultaneously occurring developments.
Each of these developments will be addressed in the course. It will for instance be reviewed why there has been an exponential increase in the identification of possible ‘drugable’ targets and why this has not necessarily translated into drug targets. Another interesting development is the greater emphasis on biomarkers to assess drug action in humans. This development, its advantages and its problems will be discussed. The role of pharmacogenetics and pharmacogenomics in current drug development as well as the exercises that are performed to link drug concentrations to drug effects will be addressed in this course. These developments will pave the road to the era of ‘personalized medicine’. This term has been coined to indicate personally tailored treatment to each individual patient. The aim of the course is gaining more insight in the application of novel techniques that are applied in pre-clinical and clinical drug research. Finally, the course aims to make the participants familiar with the current legal and regulatory requirements for drug research in humans.
Mode of instruction
The course program will consist of plenary (informative) lectures, workgroups, self-study assignments and a classroom experiment.
Although some drugs and treatments of diseases will be discussed, the course will not emphasize on pharmacotherapeutics in a broad sense.