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Physiology, Advanced Concepts


Admission requirements

The course Physiology, Advanced Concepts, is meant for the student who has already followed the course Physiology, Basic Concepts, or has a comparable level of knowledge on cardiovascular, respiratory and renal physiology.


Period: February 29 – March 18, 2016

This course focuses on impaired circulation as a result of inflammation, sepsis, endothelial dysfunction, thrombosis, atherosclerosis and vascular remodelling and its consequences for heart, lung and kidney physiology. Subtopics that will be discussed during the course are:

  • endothelial (dys)function

  • (ab)normal hemostasis

  • sepsis

  • vascular responses to Toll-like receptor activation

  • inflammatory & ischemic kidney disease

  • pulmonary arterial hypertension

  • atherosclerosis, coronary artery disease & myocardial infarction

  • heart failure: hemodynamic & electrophysiological effects

Course objectives

After having followed this course, students should have a clear understanding of the major pathophysiological processes involved in blood flow impairment and its consequences for heart, lung and kidney function.

Mode of instruction

This course consists of lectures, seminars, working groups, self-study assignments and, possibly, a patient demonstration.

Assessment method

Multiple choice exam.

Reading list

  • Boron WF & Boulpaep EL. Medical physiology: a cellular and molecular approach. Second updated edition. 2012. Saunders Elsevier, Philadelpia, PA.

  • Levick JR. Introduction to cardiovascular physiology. Fifth edition. 2010. Hodder Arnold, London, United Kingdom.

  • Versteeg HH et al. New fundamentals in hemostasis. Physiol Rev. 2013; ;93:327-358.

  • Other selected scientific papers and parts of other text books.