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Electrical Interactions in the Heart: From Disease to Treatment

Course 2018-2019

Admission requirements

Recommended prior knowledge:
Physiological Basic Concepts and Physiology Advanced Concepts, or equivalent knowledge of physiology obtained through courses elsewhere. Literature: Cardiac electrophysiology: from cell to bedside by Zipes and Jalife (Walaeus library).


Period: 13 May 2019 - 31 May 2019

First week:
Lectures will be given about important subjects related to this course, involving 1) basic cardiac electrophysiology, 2) basics of stem cell biology, 3) basics of gene therapy. At the end of this week the students need to decide what aspects have their particular interest, think about ways to study these aspects, and present their ideas in a plenary session. Throughout the week a number of scientific articles will be discussed.

Second week:
The students, which are operating in duos, will meet the PhD students, visit the labs and start their experiments. Throughout the week a number of scientific articles will be discussed.

Third week:
The students will continue with their experiments in the lab. The course will be closed by the students presenting their work. In addition, they will submit their abstracts and/or proposal for future experiments.

Research competences:
How to design and perform experiments.

Professional competences:
Commitment, motivation and drive, assertiveness and making a mark

Course objectives

The student:
1… can explain the basic principles of cardiac electrophysiology and gene therapy.
2... explain how electrophysiology is changed in frequently occurring arrhythmia.
3... illustrate how genetic modification can influence the electrical interactions in the heart.
4…can interpret and estimate the value of scientific literature and write a correct discussion.
5... can (in pairs) draw up a research strategy, in which cardiac electrophysiology is examined by means of gene therapy.
6... can argue the results and conclusions of their own research with the knowlegde gathered in this course, and subsequently is able to make recommendations for further research.
7...demonstrates a proffessional attitude in the laboratory by being on time, showing motivation, participating and sticking to the applicable rules.


All course and group schedules are published on our LUMC scheduling website or on the LUMC scheduling app.

Mode of instruction

Plenary seminars, practical work in lab, self study assignments.

Course load

Total course load is the amount of EC’s multiplied with 28 hours.

Assessment method

Summative assessment:
* Research strategy report and presentation
* Rubric literature discussions
* Rubric professional and laboratory skills


Blackboard will be used during this course.

Reading list

Will be distributed during the course.


Registration for FOS courses, H2W, Scientific Conduct, How to start, Course on Animal Science , and CRiP and Adv concepts courses takes place in lottery rounds in the beginning of July. After the lottery rounds: if you want to register for a course you are kindly asked to contact the student administration at