Admission requirements
BSc in Biology or LST with a major in Microbiology or Molecular Biology. Other candidates should have a solid background in Molecular Biology.
Contact information
Coordinator: prof. Dr. G.P. van Wezel
Email: g.wezel@biology.leidenuniv.nl
Description
Series of lectures, selection of research papers on related topics and workshops will be given on understanding how global regulatory networks govern gene expression in bacteria. We will look at how environmental signals (e.g. nutrients, stress) are translated to switch sets of genes on and off, and how this affects metabolism, competence,development and antibiotic production. Furthermore (the control of) protein secretion will be discussed. This course includes writing of a research proposal.
At the end of the course students:
will have knowledge of the fundamental principles of global control of gene expression in bacteria
will have knowledge of technologies to analyse global gene expression profiles, such as microarrays, proteomics, and RNAseq.
will have an overview of the biotechnological applications of antibiotic-producing bacteria
will have knowledge of the problems of antimicrobial resistance and how we can manipulate bacteria to produce new bioactive compounds for drug development
will understand what is needed to write a succinct research proposal on a given subject.
can digest and present a summary of a scientific presentation with help of supporting literature
Mode of instruction
Lectures, guest lecture(s) and exercises
Language
English
Timetable
Schedule information can be found on the website of the programmes and on blackboard.
Literature
The course will be based on the presentations and on the scientific literature that will be provided during the lectures. Handouts of all presentations will be provided s PDF.
Examination
Written examination (50%)
Assignments, working in small groups on a project (33%)
Summary of guest lecture (17%)
Blackboard
Blackboard will be used for communication.
Reading list
The course will be based on the presentations and on the scientific literature that will be provided during the lectures. Handouts of all presentations will be provided s PDF.
Registration
In Usis (classnumber: 10109, deadline:18-2-2018)
Enroll in Blackboard
Exchange and Study Abroad students, please see the Prospective students website for more information on how to apply.