Part 1. Transdermal drug delivery
In this series of lectures several aspects of the skin barrier formation will be discussed in order to obtain insight in the structure and function of the skin. Normal skin as well as diseased skin will be evaluated. After this general introduction we will focus on the various delivery methods that are currently available and their applicability to several groups of drugs. In addition, the penetration routes of drugs and the interaction between the formulations and the skin will be discussed. Studies performed in vitro as well as in vivo will be included.
Part 2. Protein delivery
Protein therapeutics differ in several aspects from low-molecular-weight drugs, such as molecular weight, delivery, stability, analysis, and immunogenicity. In this short course the students will gain basic insight as to why protein therapeutics are different from conventional drugs and the implications thereof for their formulation, characterization and clinical use.
Coordinator
Prof. dr. J.A. Bouwstra, prof. dr. W. Jiskoot
Students
students Bio-Pharmaceutical Sciences.
Admittance demands
Drug Delivery Technology (300 level course 3rd year of bachelor study BFW, with the Dutch name Geneesmiddelformulering) or Interventies door geneesmiddeltoediening (course of minor Systems Pharmacology).
Method of instruction
Combination of lectures, student presentations, and discussions.
Required reading
Will be handed out during the course.
Examination
Written and/or oral exam.
minimal amount of students
At least 5 participants.
Time table
The lecture series Drug Delivery will be given from 16—27 May from 9.00 to 12.45 h. See roster for details.
Application
Email Ms. Van Gent for admission: c.van.gent@lacdr.leidenuniv.nl
Participants must apply at least 3 weeks in advance
Course objective
To broaden the knowledge of drug administration via the skin and advanced visualization methods used; to gain basic insight into several aspects of the delivery of protein drugs.