Description and Course Objectives
The development of new drugs with an action on the central nervous system (CNS) is notoriously difficult. For a proper CNS effect, the drug should have the ability to cross the BBB, and then has to find its way to the relevant target site within the CNS. This course will address the role and function of the Blood-Brain Barrier (BBB) and brain tissue distribution in research concerning CNS drug development, CNS drug delivery and CNS diseases. It will provide profound insight in the complex function of the BBB with regard to transport kinetics in health and disease.
The series of lectures will include the following themes: #1 Basic aspects of the BBB, #2 Methods for investigation of BBB transport and distribution within the brain, and #3 Pharmacokinetics of CNS drug delivery.
Coordinator
Mw. Dr. E.C.M. de Lange
Students
Students of Bio-Pharmaceutical and Biomedical Sciences or other Life Sciences.
Admittance demands
Adequate knowledge of parameters that affect local drug concentration, such as drug distribution and clearance.
Minimum number of participants: 8 students
Methods of instruction
Lectures
Literature
Suggested reading
“Drug Delivery to the Brain- Physiological Concepts, Methodologies, and Approaches”. Editors: M. Hammarlund-Udenaes, EC de Lange, and R Thorne. AAPS/ Springer Science and Business Media. 2014; ISBN 978-1-4614-9104-0
Examination
Written exam
Time table
Monday June 6th from 10.00-12.00
Monday June 6th from 15.00-17.00
Monday June 13th from 10.00-12.00
Monday June 13th from 15.00-17.00
Wednesday June 15th from 10.00-12.00
Monday June 27th from 10.00-12.00
Monday June 27th from 15.00-17.00 (Q&A session)
Exam: Wednesday, June 29th from 9.00-12.00
See roster on Blackboard for further details.
Application
Application via uSis.